The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis.
The Interleukin-23/Interleukin-17 Axis Links Adaptive and Innate Immunity in Psoriasis.
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DOI：
10.3389/fimmu.2018.01323
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发表时间：
2018
影响因子：
7.3
通讯作者：
Erpenbeck L
中科院分区：
文献类型：
--
作者：
Schön MP;Erpenbeck L
银屑病的病理生理学研究揭示了许多有趣的免疫相互作用和潜在的遗传星座。其中最突出的是先天性和适应性免疫系统的组分之间的串扰以及白细胞介素（IL）-23和-17在该网络中的关键作用。虽然IL-23驱动和维持Th17淋巴细胞的分化是清楚的，但IL-23和IL-17的调节的许多方面并不那么简单，并且直到最近才被解开。例如，我们现在知道Th17细胞不是IL-17的唯一来源，但先天免疫系统的细胞也产生大量的这种中枢效应细胞因子。此外，存在IL-17的IL-23非依赖性产生。除了其他先天性免疫细胞，嗜中性粒细胞显著有助于银屑病中IL-17相关的免疫调节，并且似乎它们采用几种机制，包括形成中性粒细胞胞外陷阱。在这里，我们努力将IL-23/IL-17轴的核心作用纳入先天性和适应性免疫系统组件之间的串扰的角度。我们的目的是更好地了解银屑病中复杂的免疫调节，这种疾病已成为慢性炎症的模型疾病。
Research into the pathophysiology of psoriasis has shed light onto many fascinating immunological interactions and underlying genetic constellations. Most prominent among these is the crosstalk between components of the innate and the adaptive immune system and the crucial role of interleukins (IL)-23 and -17 within this network. While it is clear that IL-23 drives and maintains the differentiation of Th17 lymphocytes, many aspects of the regulation of IL-23 and IL-17 are not quite as straightforward and have been unraveled only recently. For example, we know now that Th17 cells are not the only source of IL-17 but that cells of the innate immune system also produce considerable amounts of this central effector cytokine. In addition, there is IL-23-independent production of IL-17. Besides other innate immune cells, neutrophilic granulocytes prominently contribute to IL-17-related immune regulations in psoriasis, and it appears that they employ several mechanisms including the formation of neutrophil extracellular traps. Here, we strive to put the central role of the IL-23/IL-17 axis into perspective within the crosstalk between components of the innate and the adaptive immune system. Our aim is to better understand the complex immune regulation in psoriasis, a disorder that has become a model disease for chronic inflammation.
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