Dysregulation of miR-124-1 predicts favorable prognosis in acute myeloid leukemia
Dysregulation of miR-124-1 predicts favorable prognosis in acute myeloid leukemia
复制标题
miR-124-1 失调可预测急性髓系白血病的良好预后
DOI：
10.1016/j.clinbiochem.2013.09.020
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发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Qian, Zhen
中科院分区：
文献类型：
--
作者：
Chen, Xing-xing;Lin, Jiang;Qian, Zhen
目的：microRNA miR-124因其在抑制细胞生长、诱导分化和促进凋亡中的作用而被认为是肿瘤抑制因子。本研究旨在探讨miR-124 - 1在急性髓系白血病（AML）患者中的表达状况及其临床意义。结果：83例AML患者中30例（36%）miR-124-1低表达。miR-124- 1低表达组与非miR-124-1低表达组在性别、年龄和血液参数方面差异无统计学意义。t（15;17）患者中miR-124-1低表达的频率高于其他患者（62% vs 30%，P = 0.040）。miR-124-1的表达状态与9个基因（FLT 3-ITD、NPM 1、C-KIT、IDH 1/IDH 2、DNMT 3A、N/K-RAS和C/EBPA）的突变无关。miR-124-1低表达患者的总生存期和无复发生存期比无miR-124-1低表达患者的总生存期和无复发生存期延长（P = 0.052和0.045，分别）。结论：这些研究结果表明，miR-124-1低表达是一种常见事件，可能对AML的预后产生有利影响（C）2013加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objective: MicroRNA miR-124 has been suggested as a tumor suppressor for its role in inhibiting cell growth, inducing differentiation and promoting apoptosis. The present study was aimed to investigate the expression status of miR-124-1 and its clinical relevance in patients with acute myeloid leukemia (AML).Designs and methods: Real-time quantitative PCR was performed to detect the expression level of miR-124-1 in AML patients. The clinical significance of miR-124-1 expression in AML was investigated.Results: miR-124-1 underexpression was identified in 30 (36%) of 83 AML patients. No significant difference could be observed in sex, age and blood parameters between the patients with and without miR-124-1 underexpression. The frequency of miR-124-1 underexpression was higher in the patients with t(15;17) than in others (62% versus 30%, P = 0.040). The status of miR-124-1 expression was not correlated with the mutations of nine genes (FLT3-ITD, NPM1, C-KIT, IDH1/IDH2, DNMT3A, N/K-RAS and C/EBPA). The patients with miR-124-1 underexpression had borderline longer overall survival and relapse-free survival than those without miR-124-1 underexpression (P = 0.052 and 0.045, respectively).Conclusions: These findings suggest that miR-124-1 underexpression is a common event and might have a favorable impact on prognosis in AML (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.