The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema
The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema
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DOI：
10.1089/lrb.2013.1132
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发表时间：
2013-09-01
影响因子：
1.4
通讯作者：
Rockson, Stanley G.
中科院分区：
文献类型：
--
作者：
Rockson, Stanley G.
在水肿中，存在细菌病原体感染的深刻倾向。因此，重新考虑我们对循环结构中淋巴结构的独特功能定义似乎是合适的。虽然这些血管无疑发挥着至关重要的循环功能，但将这个由内皮血管和淋巴组织组成的复杂网络视为循环系统和免疫系统之间的联系似乎更合适。以这种方式来看，很明显，区域淋巴破坏的复杂生物学是这两种重要身体功能之间相互作用的表现。在小鼠模型中的实验性淋巴停滞已被用于有效地证明人水肿的病理属性，即炎症、脂肪沉积和纤维化。大规模转录证实了炎症机制的作用。小鼠研究为随后的人类水肿转化研究奠定了基础。水肿引起的许多基因表达途径与炎症反应相关，并为成功鉴定人类水肿的潜在相关循环生物标志物提供了一种实用的方法。
In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions. Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.