Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India
Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India
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DOI：
10.1007/s12664-017-0785-x
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发表时间：
2017-09-01
影响因子：
2
通讯作者：
Eapen, C. E.
中科院分区：
文献类型：
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作者：
David, Deepu;Raghavendran, Anantharam;Eapen, C. E.
本研究的目的是分析非乙型非丙型肝细胞癌（HCC）患者发生非酒精性脂肪性肝病（NAFLD）的危险因素。方法选取2012年6月至2014年11月间乙型肝炎表面抗原和丙型肝炎病毒抗体阴性的肝癌患者作为研究对象。评估所有患者NAFLD的危险因素，如糖尿病（DM）、高血压、血脂异常、代谢综合征和肥胖。结果47例非b型非c型HCC患者（男性37例，年龄60 +/- 10岁，平均+/- SD）。终末期肝病模型评分为11 +/- 4。25例患者属于儿童a级。11例（23%）患者有明显的酒精摄入史。NAFLD患病率的危险因素为肥胖24例（51%），糖尿病22例（47%），代谢综合征21例（45%），高血压16例（34%），血脂异常13例（28%）。40例（85%）患者至少有一种NAFLD危险因素。在诊断为HCC之前，至少一项NAFLD危险因素的平均持续时间为7.5年。13例（28%）患者抗hbc阳性；然而，没有一个研究患者的血液中检测到HBV DNA。结论：85%的非b型非c型HCC患者存在至少一种NAFLD危险因素。所有研究患者均无隐匿性乙型肝炎感染。在印度，NAFLD正在成为非乙型非丙型HCC的主要病因。
Aim of the study The aim of the study was to analyze the prevalence of risk factors for non-alcoholic fatty liver disease (NAFLD) in patients with non-B non-C hepatocellular carcinoma (HCC).Methods Between June 2012 and November 2014, patients with HCC, negative for hepatitis B surface antigen and hepatitis C virus antibody, were included in this study. All patients were assessed for risk factors for NAFLD such as diabetes mellitus (DM), hypertension, dyslipidemia, metabolic syndrome, and obesity.Results Forty-seven patients with non-B non-C HCC (males, 37; age, 60 +/- 10 years; mean +/- SD) were studied. Model for end-stage liver disease score was 11 +/- 4. Twenty-five patients were in Child's class A. History of significant alcohol intake was noted in 11 (23%) patients. Prevalence of risk factors for NAFLD were obesity 24 (51%), DM 22 (47%), metabolic syndrome 21 (45%), hypertension 16 (34%), and dyslipidemia 13 (28%). Forty (85%) patients had at least one risk factor for NAFLD. The mean duration of at least one NAFLD risk factor was 7.5 years, prior to diagnosis of HCC. Thirteen (28%) patients were positive for anti-HBc; however, none of the study patients had detectable HBV DNA in blood.Conclusions Eighty-five percent of the patients with non-B non-C HCC had at least one risk factor for NAFLD. None of the study patients had occult hepatitis B infection. NAFLD is emerging as the major etiological contributing factor for non-B non-C HCC in India.