Local effects of atherosclerotic plaque on arterial distensibility
Local effects of atherosclerotic plaque on arterial distensibility
复制标题
DOI：
10.1161/hy1101.095994
复制
发表时间：
2001-11-01
期刊：
影响因子：
8.3
通讯作者：
Mancia, G
中科院分区：
文献类型：
--
作者：
Giannattasio, C;Failla, M;Mancia, G
高血压、糖尿病和高胆固醇血症的特征在于动脉扩张性降低和动脉粥样硬化加速。然而，动脉硬化是这些疾病的固有特征还是动脉粥样硬化临床或亚临床病变的结果尚不清楚。我们的目的是通过直接测量人类动脉粥样硬化病变部位和近端正常部位的动脉扩张性来获得有关这一问题的信息。在10例受单侧血流动力学显著颈内动脉狭窄影响的患者（8例男性;平均+/- SEM年龄，65.2 +/-3.4岁）中，我们测量了双侧颈内动脉和颈总动脉水平的动脉扩张性（Wall Track System; PIE Medical）。在颈总动脉中，在分叉处下方3 cm处进行测量。在受影响的颈内动脉中，在斑块肩部（壁厚2 mm）进行测量。在对称水平对侧颈内动脉进行测量。在动脉扩张性相同部位测量动脉壁厚度。颈内动脉的动脉扩张性小于颈总动脉，斑块颈内动脉水平与相应的对侧部位相比显著降低（-45%，P
Hypertension, diabetes, and hypercholesterolemia are characterized by a reduction in arterial distensibility and by accelerated atherosclerosis. Whether arterial stiffening is an inherent feature of these conditions or just the consequence of the atherosclerotic clinical or subclinical lesions is not known, however. Our aim was to obtain information on this issue by directly measuring, in humans, arterial distensibility both at the site of an atherosclerotic lesion and at the proximal normal site. In 10 patients (8 men; mean +/- SEM age, 65.2 +/-3.4 years) affected by monolateral hemodynamic significant internal carotid artery stenosis, we measured arterial distensibility (Wall Track System; PIE Medical) bilaterally, both at the internal carotid artery and at the common carotid artery level. In the common carotid artery, measurements were made 3 cm below the bifurcation. In the affected internal carotid artery, measurements were made at the plaque shoulder (wall thickness of 2 mm). Measurements were made in the contralateral internal carotid artery at a symmetrical level. Arterial wall thickness was measured in the same site of arterial distensibility. Arterial distensibility was less in the internal than in the common carotid artery, with a marked reduction at the plaque internal carotid artery level compared with the corresponding contralateral site (-45%, P