Caffeine and alcohol as risk factors for sudden infant death syndrome
Caffeine and alcohol as risk factors for sudden infant death syndrome
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DOI：
10.1136/adc.81.2.107
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发表时间：
1999-08-01
影响因子：
5.2
通讯作者：
Irgens, LM
中科院分区：
文献类型：
--
作者：
Alm, B;Wennergren, G;Irgens, LM
为了评估酒精和咖啡因是否是婴儿猝死综合征（SIDS）的独立危险因素，材料和方法-基于北欧流行病学SIDS研究数据的分析，这是一项病例对照研究，其中北欧国家SIDS受害者的所有父母从1992年9月1日至1995年8月31日被邀请参加与四个对照的父母，死亡时的性别和年龄都吻合优势比（OR）计算条件logistic回归analysis.Results-The粗OR为咖啡因消费量> 800毫克/24小时，在怀孕期间和怀孕后显着提高：3.9（95%置信区间（CI），1.9至8.1）和3.1（95% CI，1.5至6.3），分别。然而，在调整了母亲在怀孕早期的吸烟情况、母亲的年龄、教育程度和产次后，咖啡因在怀孕期间或怀孕后没有显著的影响。对于母亲或父亲的酒精使用，没有显着的风险增加后，发现调整社会变量，除了大量的产后酒精摄入的母亲，在那里的风险显着increased. Conclusions咖啡因在怀孕期间或怀孕后未被发现是一个独立的危险因素调整后的母亲的年龄，教育，奇偶校验，并在怀孕期间吸烟的小岛屿发展中国家。母亲在出生后大量饮酒而不是在出生前饮酒会增加风险。
Objective-To assess whether alcohol and caffeine are independent risk factors for sudden infant death syndrome (SIDS).Materials and methods-Analyses based on data from the Nordic epidemiological SIDS study, a case control study in which all parents of SIDS victims in the Nordic countries from 1 September 1992 to 31 August 1995 were invited to participate with parents of four controls, matched for sex and age at death. Odds ratios (ORs) were calculated by conditional logistic regression analysis.Results-The crude ORs for caffeine consumption > 800 mg/24 hours both during and after pregnancy were significantly raised: 3.9 (95% confidence interval (CI), 1.9 to 8.1) and 3.1 (95% CI, 1.5 to 6.3), respectively. However, after adjustment for maternal smoking in Ist trimester, maternal age, education and parity, no significant effect of caffeine during or after pregnancy remained. For maternal or paternal alcohol use, no significant risk increase was found after adjusting for social variables, except for heavy postnatal intake of alcohol by the mother, where the risk was significantly increased.Conclusions-Caffeine during or after pregnancy was not found to be an independent risk factor for SIDS after adjustment for maternal age, education, parity, and smoking during pregnancy. Heavy postnatal but not prenatal intake of alcohol by the mother increased the risk.