Programmable Assembly of Nano‐architectures through Designing Anisotropic DNA Origami Patches
Programmable Assembly of Nano‐architectures through Designing Anisotropic DNA Origami Patches
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通过设计各向异性 DNA 折纸补丁实现纳米结构的可编程组装
DOI：
10.1002/anie.201913958
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tian Ye
中科院分区：
文献类型：
--
作者：
Wang Mingyang;Dai Lizhi;Duan Jialin;Ding Zhiyuan;Wang Peng;Li Zheng;Xing Hang;Tian Ye
将纳米颗粒（NP）可编程地组装成定义明确的结构已经引起了人们的关注，因为耦合效应产生了定制的特性。然而，一般和精确的方法来控制纳米颗粒之间的结合模式仍然是一个挑战，由于在操纵纳米颗粒表面上的功能补丁的准确位置的困难。在这里，开发了一种策略，通过DNA碱基配对将球形NP包裹到预先设计的八面体DNA折纸框架（DOF）中。由于DNA杂交的可编程性，DOF在逻辑上定义了功能块在三维中的排列，从而控制了具有设计各向异性的笼状纳米颗粒的结合模式。应用晶体工程中广泛使用的节点和间隔区方法设计配位聚合物，可以合理设计具有较低对称性编码的片状纳米颗粒，以组装一系列具有高阶几何形状的纳米结构。
Programmable assembly of nanoparticles (NPs) into well‐defined architectures has attracted attention because of tailored properties resulting from coupling effects. However, general and precise approaches to control binding modes between NPs remain a challenge owing to the difficulty in manipulating the accurate positions of the functional patches on the surface of NPs. Here, a strategy is developed to encage spherical NPs into pre‐designed octahedral DNA origami frames (DOFs) through DNA base‐pairings. The DOFs logically define the arrangements of functional patches in three dimensions, owing to the programmability of DNA hybridization, and thus control the binding modes of the caged nanoparticle with designed anisotropy. Applying the node‐and‐spacer approach that was widely used in crystal engineering to design coordination polymers, patchy NPs could be rationally designed with lower symmetry encoded to assemble a series of nano‐architectures with high‐order geometries.