Use of antimicrobials in companion animal practice: a retrospective study in a veterinary teaching hospital in Italy
Use of antimicrobials in companion animal practice: a retrospective study in a veterinary teaching hospital in Italy
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DOI：
10.1093/jac/dkq543
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发表时间：
2011-04-01
影响因子：
5.2
通讯作者：
Scavia, Gaia
中科院分区：
文献类型：
--
作者：
Escher, Martina;Vanni, Michele;Scavia, Gaia
目的：描述使用抗菌药物的兽医教学医院的伴侣动物在意大利，特别是关于协议的建议，谨慎使用方法：这项研究进行了回顾性，横断面设计。研究对象包括2000年至2007年期间被转诊到医院的18905只猫和狗。随机选择两种不同的临床论文样本，以估计接受抗菌药物处方的动物的患病率，并描述与治疗疾病相关的抗菌药物使用模式。抗菌药物的比例也估计完成谨慎使用的建议，以及协议的水平与具体的，诊断为基础的指南抗菌use.Results：广谱抗菌药物，包括青霉素与β-内酰胺酶抑制剂，第一代头孢菌素和氟喹诺酮类药物，是最常见的处方化合物。在微生物分析和药敏试验支持下处方的抗菌剂低于5%。在谨慎使用的建议，从实验室检测的信息的可用性有最差的程度的协议，而其他评估项目完成在大多数cases.Conclusions：我们的研究结果强调，需要改善程序的抗菌药物处方的研究设置。要做到这一点，可以在地方一级通过具体的指导方针，支持抗菌药物使用指南，在国家一级进一步执行谨慎处方政策。
Objectives: To describe the use of antimicrobials in a veterinary teaching hospital for companion animals in Italy, with particular regard to the agreement with recommendations of prudent useMethods: The study was conducted with a retrospective, cross-sectional design. The population under investigation included 18905 cats and dogs that were referred to the hospital between 2000 and 2007. Two different samples of the clinical paper forms were randomly selected to estimate the prevalence of animals receiving an antimicrobial prescription and to describe the pattern of antimicrobials used in relation to the condition being treated. The proportion of antimicrobials prescribed accomplishing recommendations of prudent use was also estimated, as well as the level of agreement with specific, diagnosis-based guidelines for antimicrobial use.Results: Broad-spectrum antimicrobials, including penicillins with beta-lactamase inhibitors, first-generation cephalosporins and fluoroquinolones, were the most frequently prescribed compounds. Antimicrobials prescribed with the support of microbiological analyses and susceptibility testing were less than 5%. Among the recommendation of prudent use, the availability of information from laboratory testing had the poorest degree of agreement, while the other evaluated items were accomplished in most of the cases.Conclusions: Our results highlight the need to improve the procedures of antimicrobial prescription in the study setting. This can be achieved by supporting the guidance for antimicrobial use at the local level, with the adoption of specific guidelines, and at the national level with a further implementation of the policies of prudent prescriptions.