Reduced cerebellar left hemisphere and vermal volume in adults with PTSD from a community sample
Reduced cerebellar left hemisphere and vermal volume in adults with PTSD from a community sample
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DOI：
10.1016/j.jpsychires.2011.07.013
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发表时间：
2011-12-01
影响因子：
4.8
通讯作者：
Bressan, Rodrigo A.
中科院分区：
文献类型：
--
作者：
Baldacara, Leonardo;Jackowski, Andrea P.;Bressan, Rodrigo A.
背景资料：创伤性事件暴露是创伤后应激障碍（PTSD）发生的必要条件，但并非所有个体暴露于相同的创伤后都会发生PTSD。人类研究表明，小脑参与人类的恐惧感知，预期和回忆。在这种情况下，目前的研究评估小脑体积是否与PTSD.Methods：84暴力的受害者，42谁履行了DSM-IV-TR标准的PTSD和42弹性控制，确定通过在城市进行的流行病学调查530保罗。受试者使用临床医生管理的PTSD量表（CAPS），贝克焦虑量表（BAI），贝克抑郁量表（BDI）和早期创伤量表（ETI）进行评估。所有受试者进行了磁共振成像（MRI）扫描，以评估他们的小脑半球和vermis.Results：PTSD受试者有相对较小的左半球（p = 0.04）和小脑蚓部（p < 0.01）的体积持续控制后的性别，年龄和脑容量。在PTSD组中，左小脑半球体积与PTSD（p = 0.01）和抑郁症状（p = 0.04）呈负相关。小脑体积与PTSD症状（p < 0.01）、早期创伤性生活事件（p < 0.01）、抑郁症状（p = 0.04）和焦虑症状（p = 0.01）呈负相关。早期创伤性生活经历与睾丸体积减少有关，可能是未来PTSD发展的危险因素。(C)2011爱思唯尔有限公司版权所有。
Background: Traumatic events exposure is a necessary condition for developing posttraumatic stress disorder (PTSD), but not all individuals exposed to the same trauma will develop PTSD. Human studies have suggested that the cerebellum is involved in human fear perception, anticipation, and recollection. In this context, the current study evaluated whether cerebellar volume is associated with PTSD.Methods: Eighty-four victims of violence, 42 who fulfilled the DSM-IV-TR criteria for PTSD and 42 resilient controls, were identified through an epidemiologic survey conducted in the city of 530 Paulo. Subjects were evaluated using the Clinician-Administered PTSD Scale (CAPS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Early Trauma Inventory (ETI). All subjects underwent a magnetic resonance imaging (MRI) scan to evaluate their cerebellar hemispheres and vermis.Results: PTSD subjects had relative smaller left hemisphere (p = 0.04) and vermis (p < 0.01) volumes persisted after controlling for gender, age, and brain volume. In PTSD group, left cerebellar hemisphere volume correlated negatively with PTSD (p = 0.01) and depressive symptoms (p = 0.04). Vermal volume correlated negatively with PTSD symptoms (p < 0.01), early traumatic life events (p < 0.01), depressive symptoms (p = 0.04) and anxiety (p = 0.01).Conclusion: The cerebellum is involved in emotion modulation, and our results suggest that cerebellar volumetric reduction is associated with mood, anxiety and PTSD symptoms. Early traumatic life experiences are related to vermal volume reduction and may be a risk factor for future PTSD development. (C) 2011 Elsevier Ltd. All rights reserved.