Rapid, systematic updating of movement by accumulated decision evidence.
Rapid, systematic updating of movement by accumulated decision evidence.
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通过积累的决策证据快速、系统地更新运动。
DOI：
10.1101/2023.11.09.566389
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Hyafil,Alexandre
中科院分区：
文献类型：
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作者：
Molano-Mazón,Manuel;Garcia-Duran,Alexandre;Pastor-Ciurana,Jordi;Hernández-Navarro,Lluís;Bektic,Lejla;Lombardo,Debora;delaRocha,Jaime;Hyafil,Alexandre
在自然界中行动不仅需要在多个选项中做出决定，还需要将决定转化为运动指令。然而，决策形成的动力学如何影响反应运动的精细运动学仍然知之甚少。在这里，我们研究如何积累的决策证据形状的反应定向轨迹在一个任务中，自由移动的大鼠结合联合收割机先前的期望和听觉信息，选择两个可能的选项。响应轨迹和它们的运动活力最初由先验确定。然后，大鼠的运动在刺激开始后不到100 ms的时间内通过加速或减慢来整合感官信息，这取决于刺激支持其最初选择的程度。当刺激证据存在强烈的矛盾时，老鼠会改变主意，扭转它们最初的轨迹。执行相同任务的人类受试者表现出非常相似的行为。我们将这些结果封装在一个计算模型中，该模型将决策变量映射到离散时间点的运动学上，捕获受试者的选择，轨迹和思想变化。我们的研究结果表明，运动反应不是弹道。相反，随着时间的推移，它们会随着基本决策过程的并行动态而系统地、快速地更新。
Acting in the natural world requires not only deciding among multiple options but also converting decisions into motor commands. How the dynamics of decision formation influence the fine kinematics of response movement remains, however, poorly understood. Here we investigate how the accumulation of decision evidence shapes the response orienting trajectories in a task where freely-moving rats combine prior expectations and auditory information to select between two possible options. Response trajectories and their motor vigor are initially determined by the prior. Rats movements then incorporate sensory information in less than 100 ms after stimulus onset by accelerating or slowing depending on how much the stimulus supports their initial choice. When the stimulus evidence is in strong contradiction, rats change their mind and reverse their initial trajectory. Human subjects performing an equivalent task display a remarkably similar behavior. We encapsulate these results in a computational model that maps the decision variable onto the movement kinematics at discrete time points, capturing subjects’ choices, trajectories and changes of mind. Our results show that motor responses are not ballistic. Instead, they are systematically and rapidly updated, as they smoothly unfold over time, by the parallel dynamics of the underlying decision process.