The Current State of Pancreatic Cancer in Canada Incidence, Mortality, and Surgical Therapy
The Current State of Pancreatic Cancer in Canada Incidence, Mortality, and Surgical Therapy
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DOI：
10.1097/mpa.0000000000000147
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发表时间：
2014-08-01
期刊：
影响因子：
2.9
通讯作者：
Molinari, Michele
中科院分区：
文献类型：
--
作者：
Hurton, Scott;MacDonald, Frank;Molinari, Michele
目的：本研究旨在评估加拿大胰腺癌（PC）患者的发病率、生存率和手术治疗趋势。方法：从加拿大癌症数据库中提取按年、性别和省份分层的PC患者的发病率、死亡率、手术次数和结局。结果：2012年，4600名加拿大人被诊断为PC， 4300人死亡。年龄标准化发病率为每10万人9至10例新发病例。死亡率在所有实体瘤中最高，病死率为0.93。年龄标准化5年相对生存率为9.1%（95%可信区间[CI]， 8.3-10）。各省之间存在地理差异，安大略省的存活率最高（10.9%,95% CI, 9.9-12），新斯科舍省的存活率最低（4.7%,95% CI, 2.8-7.2）。接受手术的患者比例从2006-2007年的19%下降到2009-2010年的17%。74%的病例在大容量中心进行胰腺切除术。住院死亡率为5%，93%的患者出院回家，36%的患者出院后需要家庭支持。结论：加拿大PC患者的长期预后仍然不令人满意，只有9%的患者存活至5年。只有17% - 19%的患者接受了手术治疗。
Objective: This study aimed to evaluate the trends in the incidence, survival, and surgical therapy for Canadian patients affected by pancreatic cancer (PC).Methods: The incidence, mortality, number of resections, and outcomes of patients with PC stratified by year, sex, and province were extracted from Canadian cancer databases.Results: In 2012, PC was diagnosed in 4600 Canadians and it was responsible for 4300 deaths. The age-standardized incidence was 9 to 10 new cases per 100,000 individuals. The mortality rate remained the highest among all the solid tumors with a case-to-fatality ratio of 0.93. The age-standardized 5-year relative survival was 9.1% (95% confidence interval [CI], 8.3-10). There were geographic variations among provinces with the highest survival registered in Ontario (10.9%; 95% CI, 9.9-12) and the lowest survival reported in Nova Scotia (4.7%; 95% CI, 2.8-7.2). The percentage of patients who underwent surgery decreased from 19% (2006-2007) to 17% (2009-2010). Pancreatic resections were performed in high-volume centers in 74% of cases. In-hospital mortality was 5%, 93% of patients were discharged home, and 36% of patients required home support after discharge.Conclusions: Long-term outcomes of Canadian patients affected by PC remain unsatisfactory, with only 9% of the patients surviving at 5 years. Surgical therapy was performed only in 17% to 19% of patients.