Developmentally inspired drug prevention: middle school outcomes in a school-based randomized prevention trial
Developmentally inspired drug prevention: middle school outcomes in a school-based randomized prevention trial
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DOI：
10.1016/j.drugalcdep.2003.10.002
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发表时间：
2004-02-07
影响因子：
4.2
通讯作者：
Kellam, SG
中科院分区：
文献类型：
--
作者：
Furr-Holden, CDM;Ialongo, NS;Kellam, SG
先前的调查已经将小学的行为能力与后来参与药物的风险降低联系起来。在这项随机预防试验中，我们试图量化两种发展启发的普遍预防干预措施对早发性酒精，吸入剂，烟草和非法药物使用的风险的潜在早期影响。参与者被招募，因为他们进入一年级的九所学校的城市公立学校系统。大约80%的样本从一年级到八年级。本研究设计了两种以理论为基础的预防性干预措施，（1）家庭-学校伙伴关系（FSP）干预措施和（2）以课堂为中心（CC）干预措施，以改善小学生的早期危险行为。广义估计方程（GEE）多变量响应曲线回归用于估计干预青年与对照组（即标准教育环境中的青年）药物参与的相对曲线。相对于对照组青少年，干预组青少年不太可能使用烟草，与FSP干预相关的保护（RR = 0.6; P = 0.042）相比，与CC干预相关的保护（RR = 0.5; P = 0.008）的证据略强。干预状态与开始使用酒精、吸入剂或大麻的风险无关，但分配到CC干预与青春期早期开始使用其他非法药物（即海洛因、快克和可卡因粉）的风险降低相关（RR = 0.32，P = 0.042）。这项研究增加了新的证据，表明与干预相关的开始使用非法药物的风险降低。在“网关”模型的背景下，大麻的无效证据是耐人寻味的，值得在未来的调查中注意。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Prior investigations have linked behavioral competencies in primary school to a reduced risk of later drug involvement. In this randomized prevention trial, we sought to quantify the potential early impact of two developmentally inspired universal preventive interventions on the risk of early-onset alcohol, inhalant, tobacco, and illegal drug use through early adolescence. Participants were recruited as they entered first grade within nine schools of an urban public school system. Approximately, 80% of the sample was followed from first to eighth grades. Two theory-based preventive interventions, (1) a family-school partnership (FSP) intervention and (2) a classroom-centered (CC) intervention, were developed to improve early risk behaviors in primary school. Generalized estimating equations (GEE) multivariate response profile regressions were used to estimate the relative profiles of drug involvement for intervention youths versus controls, i.e. youth in the standard educational setting. Relative to control youths, intervention youths were less likely to use tobacco, with modestly stronger evidence of protection associated with the CC intervention (RR = 0.5; P = 0.008) as compared to protection associated with the FSP intervention (RR = 0.6; P = 0.042). Intervention status was not associated with risk of starting alcohol, inhalants, or marijuana use, but assignment to the CC intervention was associated with reduced risk of starting to use other illegal drugs by early adolescence, i.e. heroin, crack, and cocaine powder (RR = 0.32, P = 0.042). This study adds new evidence on intervention-associated reduced risk of starting illegal drug use. In the context of 'gateway' models, the null evidence on marijuana is intriguing and merits attention in future investigations. (C) 2003 Elsevier Ireland Ltd. All rights reserved.