Otoprotectants: From Research to Clinical Application.
Otoprotectants: From Research to Clinical Application.
复制标题
耳保护剂：从研究到临床应用。
DOI：
10.1055/s-0039-1684045
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发表时间：
2019
影响因子：
--
通讯作者：
LePrell,ColleenG
中科院分区：
文献类型：
--
作者：
LePrell,ColleenG
迫切需要耳保护药物。尽管要求高危人群使用耳塞或耳罩等听力保护设备，但预防噪声引起的听力损失仍然是军事人员和各行业工人面临的主要挑战。药物引起的听力损失也是一个主要的生活质量问题，许多患者因顺铂和氨基糖苷类抗生素等救生药物治疗的副作用而出现临床上严重的听力损失。美国食品和药物管理局尚未批准用于保护内耳免受损伤并预防相关听力损失（耳保护）的药剂。然而，各种临床前研究表明了其前景，并且现在也可以获得一些来自临床试验的支持数据。迫切需要在这个有前景的领域进行更多研究。
There is an urgent need for otoprotective drug agents. Prevention of noise-induced hearing loss continues to be a major challenge for military personnel and workers in a variety of industries despite the requirements that at-risk individuals use hearing protection devices such as ear plugs or ear muffs. Drug-induced hearing loss is also a major quality-of-life issue with many patients experiencing clinically significant hearing loss as a side effect of treatment with life-saving drug agents such as cisplatin and aminoglycoside antibiotics. There are no pharmaceutical agents approved by the United States Food and Drug Administration for the purpose of protecting the inner ear against damage, and preventing associated hearing loss (otoprotection). However, a variety of preclinical studies have suggested promise, with some supporting data from clinical trials now being available as well. Additional research within this promising area is urgently needed.