Acute myocardial infarction treated by glucose-insulin-potassium (GIK) infusion.
Acute myocardial infarction treated by glucose-insulin-potassium (GIK) infusion.
复制标题
葡萄糖-胰岛素-钾（GIK）输注治疗急性心肌梗塞。
DOI：
10.1159/000168928
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发表时间：
1966
期刊：
影响因子：
--
通讯作者：
J. Karnell
中科院分区：
文献类型：
--
作者：
J. Sievers;J. Lindh;B. Johansson;J. Karnell
急性心肌梗死具有很高的死亡率，大多数斯堪的纳维亚作家都认为死亡率约为30%。这一可观的数字在过去30年中并没有减少，对1935年至1960年期间马利诺3000多起枪击案件的分析证实了这一点(Siever，1964)。此外，这种情况的频率正在增加，特别是在生活水平较高的国家。因此，提出并尝试了几种治疗措施是很自然的。在我们的临床尝试中，类固醇治疗的效果值得一提的是(Sieves等人，1964)。近年来几位作者提出的一种治疗方法是静脉输注葡萄糖、胰岛素和钾(GIK疗法)。早在1930年，Be//等人(1930)就提出了类似的想法，他们建议用静脉注射葡萄糖进行治疗。1956年，实验室讨论了葡萄糖、胰岛素和钾的治疗(1956、1963)，法国的其他工作者也报告了他们的经验(Guiran等人，1964)。庞塞·德·莱昂等人。在墨西哥城(1962)，在狗和心肌梗塞患者中都使用了GIK疗法。Josipovic(1964)，Fritz(1965)和Orinius(1965)也报道了这种作用的结果。细胞内钾离子含量的增加是通过给予葡萄糖和胰岛素实现的(Surawics等人，1963)。由于急性脑梗塞周边缺血区的电生理学特征是复极能力降低，建议的治疗方法是为了增强转移率。
Acute myocardial infarction carries a high mortality, which most Scandinavian authors agree to be approximately 30 per cent. This considerable figure has not lessened during the past 30 years, which has been borne out by an analysis of more than 3000 in farction cases in Malino during the years 1935-1960 (Sievers, 1964). In addition the frequency of the condition is increasing, particu larly in countries with high living standards. It is thus natural that several therapeutic measures have been proposed and tried. Among those attempted in our clinic the effect of steroid therapy is worthy of mention (Sievers et al., 1964|. A treatment proposed by several authors during recent years is the intravenous infusion of glucose, insulin and potassium (GIK-treatment). A similar idea was proposed as early as 1930 by Be//et al.(1930), who suggested treatment with intravenous dextrose. In 1956 treatment with glucose, insulin and potassium was dis cussed by Laboril (1956, 1963) and also other workers in France have reported their experiences (Guiran et al., 1964). Ponce de León el al. in Mexico City (1962) used GIK-treatment both in dogs and patients with myocardial infarction. The results of such medi cation have also been reported by Josipovic (1964), Fritz (1965) and Orinius (1965).An increased intracellular content of potassium ions is achieved by administering glucose and insulin (Surawics et al., 1963). Since the ischaemic zone in the periphery of an acute infarct is charac terized electrophysiologicaDy by a decreased ability of repolari zation, the proposed treatment is meant to enhance the transpor