Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease.
Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease.
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炎症性肠病的诊断和纳米载体精准治疗的最新进展
DOI：
10.2147/jir.s304101
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发表时间：
2021
影响因子：
4.5
通讯作者：
Yang H
中科院分区：
文献类型：
--
作者：
Wang L;Yu M;Yang H
摘要结肠有效给药是炎症性肠病（IBD）治疗的国际前沿研究课题。具有巨大潜力的基于纳米载体的纳米药物的探索和研究为IBD的治疗和诊断带来了新的机遇。具有不同形态和特性的功能性纳米载体不仅可以有效避免对复杂的胃肠道微环境的破坏，而且可以赋予药物靶向治疗和提高生物利用度，从而提高治疗效率。本文综述了IBD治疗面临的挑战，重点介绍了纳米粒口服、直肠给药和肠外给药的最新研究进展，以及IBD的诊断。最后，我们展望了纳米载体在IBD治疗和诊断中的应用前景。
Abstract The effective colon drug delivery remains to be an international frontier research in inflammatory bowel disease (IBD) therapy. The exploration and research of nanocarrier-based nanomedicine with great potential brings new opportunities for IBD therapy and diagnoses. Functional nanocarriers with varying morphology and characteristics can not only effectively avoid the destruction of the complex gastrointestinal (GI) tract microenvironment but also endow drugs with target therapy and improved bioavailability, thus elevating therapeutic efficacy. In this review, we illustrated several challenges in IBD therapy, then emphasis on some latest research progress of nanoparticles based therapy of oral administration, rectal administration and parenteral administration, as well as IBD diagnoses. Finally, we described the future perspective of nanocarriers in the treatment and diagnoses of IBD.