Where does Parkinson disease pathology begin in the brain?
Where does Parkinson disease pathology begin in the brain?
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DOI：
10.1093/jnen/61.5.413
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发表时间：
2002-05-01
影响因子：
3.2
通讯作者：
Braak, H
中科院分区：
文献类型：
--
作者：
Del Tredici, K;Rüb, U;Braak, H
黑质不是帕金森病（PD）神经退行性过程的大脑诱导部位。相反，对30例附带路易体病理学的尸检病例的半定量研究结果表明，脑中的PD始于背侧舌咽-迷走神经复合体的非儿茶酚胺能神经元中的第一个免疫反应性路易神经突和路易体的形成，中间网状带的投射神经元中，和增益设定系统的特定神经细胞类型（蓝斑-蓝斑下复合体，尾中缝核。在黑质不受累的情况下，嗅球、嗅束和/或前嗅核。这里描述的核格雷的地形学分组是基于对人类脑干的已知结构分析，并考虑了参与PD的几种高度易感神经细胞类型的色素沉着特性。在这个样本和所有58个年龄和性别匹配的对照中，路易体和路易神经突不出现在任何已知的前脑好发部位（即海马结构）。颞叶中皮层，前新皮层扣带区，杏仁核。Meynert基底核Broca斜角带间质核，下丘脑结节乳头核）。
The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immunoreactive Lewy neurites and Lewy bodies in non-catecholaminergic neurons of the dorsal glossopharyngeus-vagus complex, in projection neurons of the intermediate reticular zone, and in specific nerve cell types of the gain setting system (coeruleus-subcoeruleus complex, caudal raphe nuclei. gigantocellular reticular nucleus), olfactory bulb, olfactory tract, and/or anterior olfactory nucleus in the absence of nigral involvement. The topographical parcellation of the nuclear grays described here is based upon known architectonic analyses of the human brainstem and takes into consideration the pigmentation properties of a few highly susceptible nerve cell types involved in PD. In this sample and in all 58 age- and gender-matched controls, Lewy bodies and Lewy neurites do not occur in any of the known prosencephalic predilection sites (i.e. hippocampal formation. temporal mesocortex, pro-neocortical cingulate areas, amygdala. basal nucleus of Meynert. interstitial nucleus of the diagonal band of Broca, hypothalamic tuberomamillary nucleus).