Improving the catalytic performance of peroxidases in organic synthesis.
Improving the catalytic performance of peroxidases in organic synthesis.
复制标题
DOI：
10.1016/s0167-7799(00)01529-8
复制
发表时间：
2001-02
影响因子：
17.3
通讯作者：
F. V. D. Velde;F. V. Rantwijk;R. Sheldon
中科院分区：
文献类型：
--
作者：
F. V. D. Velde;F. V. Rantwijk;R. Sheldon
过氧化物酶是一种普遍存在的酶，可催化多种与过氧化氢 (H2O2) 发生的对映选择性氧转移反应。尽管它们具有巨大的潜力，但其工业应用因其高价格和低运行稳定性而受到阻碍。最近的发展，如氧化剂的控制添加和原位形成、蛋白质工程和半合成过氧化物酶的合理设计，旨在提高过氧化物酶的操作稳定性。
Peroxidases are ubiquitous enzymes that catalyze a variety of enantioselective oxygen-transfer reactions with hydrogen peroxide (H2O2). Although they have enormous potential, their industrial application is hampered by their high price and low operational stability. Recent developments, such as the controlled addition andin situformation of the oxidant, protein engineering and the rational design of semi-synthetic peroxidases, aim to improve the operational stability of peroxidases.