Organosilicon Molecules with Medicinal Applications
Organosilicon Molecules with Medicinal Applications
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DOI：
10.1021/jm3010114
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发表时间：
2013-01-24
影响因子：
7.3
通讯作者：
Wilson, Sean O.
中科院分区：
文献类型：
--
作者：
Franz, Annaliese K.;Wilson, Sean O.
硅的掺入和有机硅小分子的合成为医药应用提供了独特的机会。有机硅小分子的生物学研究是特别有趣的，因为它们的化学性质的差异，可以有助于提高效力和改善药理学属性。应用，如抑制剂的设计，成像，药物释放技术，并映射抑制剂结合进行了讨论。
The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.