The biological embedding of early experience and its effects on health in adulthood
The biological embedding of early experience and its effects on health in adulthood
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DOI：
10.1111/j.1749-6632.1999.tb08107.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Hertzman, C
中科院分区：
文献类型：
--
作者：
Hertzman, C
阐述健康状况的社会经济梯度时，必须考虑到以下观察结果，即梯度跨越广泛的疾病过程，并能够在社会中出现新的疾病过程时自我复制。理解这种模式需要理解人类有机体如何随着时间的推移变得普遍脆弱或对疾病有弹性：这是一项跨不同学科的巨大整理任务。最符合当前证据的假设是，梯度是人的发展状况与他们在生命历程中遇到的物质和心理社会条件之间相互作用的“涌现属性”。在这一广泛的提法，特别注意儿童的发展，以及前景，社会经济差异的质量，早期生活经验有助于随后梯度的健康状况，通过社会经济差异的大脑塑造和空调主机防御系统，依赖于通信与发展中的大脑。从理论上讲，健康梯度的贡献是通过潜在效应、途径效应和累积不利因素的组合发生的。
Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organisms can become generally vulnerable or resilient to disease over time: a huge collation task across different disciplines. The hypothesis that best fits current evidence is that the gradient is an " emergent property" of the interaction between the developmental status of people and the material and psychosocial conditions they encounter over their life course. Within this broad formulation, special attention is given to child development, and the prospect that socioeconomic differences in the quality of early life experiences contribute to subsequent gradients in health status through socioeconomic differences in brain sculpting and the conditioning of host defense systems that depend on communication with the developing brain. The contribution to the gradient in health is theorized to occur through a combination of latent effects, pathway effects, and cumulative disadvantage.