Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study.
Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study.
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DOI：
10.1161/circgenetics.109.853630
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发表时间：
2009-08
期刊：
影响因子：
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通讯作者：
North KE
中科院分区：
文献类型：
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作者：
Franceschini N;Rose KM;Storti KL;Rutherford S;Voruganti VS;Laston S;Göring HH;Dyer TD;Umans JG;Lee ET;Best LG;Fabsitz RR;Cole SA;MacCluer JW;North KE
人口研究表明，社会、行为和环境因素在血压水平中起着重要作用。考虑这些因素的遗传相互作用可能有助于确定常见的血压易感性等位基因。我们研究了加性遗传效应、行为（体育活动、吸烟、饮酒）和社会经济（教育）因素对血压的相互作用，使用方差成分模型研究了大约3600名美国印第安人强心脏家庭研究参与者。静息收缩压和舒张压的平均值和标准差分别为123±17和76±11 mm Hg。我们发现与从不吸烟者相比，曾经吸烟者对舒张压有明显的遗传影响（P=0.01）。对于酒精摄入，我们观察到基因型与环境的显著相互作用对当前饮酒者的舒张压（ρg=0.10, P = 0.0003）和收缩压（ρg= 0.59, P = 0.0008）的影响。我们还检测到基因型-体力活动对舒张压的相互作用（ρg=0.35, P = 0.0004）。最后，有证据表明，与受过12年或以上教育的人相比，受教育程度低于高中的人对舒张压有明显的遗传影响（ρg= 0.41, P = 0.02）。我们的研究结果表明，行为和社会经济因素可以改变遗传对血压表型的影响。考虑环境依赖因素可能有助于我们更好地理解基因对血压和其他具有高水平遗传异质性的复杂表型的影响的复杂性。
Population studies have demonstrated an important role of social, behavioral, and environmental factors in blood pressure levels. Accounting for the genetic interaction of these factors may help to identify common blood pressure susceptibility alleles. We studied the interaction of additive genetic effects and behavioral (physical activity, smoking, alcohol use) and socioeconomic (education) factors on blood pressure in approximately 3,600 American Indians participants of the Strong Heart Family Study, using variance component models. The mean and standard deviation of resting systolic and diastolic blood pressures were 123 ± 17 and 76 ± 11 mm Hg, respectively. We detected evidence for distinct genetic effects on diastolic blood pressure among ever smokers compared to never smokers (P=0.01). For alcohol intake, we observed significant genotype-by-environment interactions on diastolic (ρg=0.10, P = 0.0003) and on systolic blood pressures (ρg= 0.59, P = 0.0008) among current drinkers compared to former or never drinkers. We also detected genotype-by-physical activity interactions on diastolic blood pressure (ρg=0.35, P = 0.0004). Lastly, there was evidence for distinct genetic effects on diastolic blood pressure among individuals with less than high school education compared to those with 12 or more years of education (ρg= 0.41, P = 0.02). Our findings suggest that behavioral and socioeconomic factors can modify the genetic effects on blood pressure phenotypes. Accounting for context dependent factors may help us to better understand the complexities of the gene effects on blood pressure and other complex phenotypes with high levels of genetic heterogeneity.