Multimodal treatment for locally advanced breast cancer. Result of chemotherapy-radiotherapy versus chemotherapy-surgery.
Multimodal treatment for locally advanced breast cancer. Result of chemotherapy-radiotherapy versus chemotherapy-surgery.
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局部晚期乳腺癌的多模式治疗。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
G. Bonadonna
中科院分区：
文献类型：
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作者：
M. Delena;M. Varini;R. Zucali;D. Rovini;G. Viganotti;P. Valagussa;U. Veronesi;G. Bonadonna
在一项前瞻性随机研究中，对132名局部晚期乳腺癌患者进行了两种联合治疗方法(化疗+放射治疗或化疗+乳房切除术)的疗效测试。化疗包括阿霉素加长春新碱(AV)，在局部-区域方案之前进行三个周期，然后再进行七个周期。虽然乳腺癌切除后完全缓解的女性比例(100%)高于接受放射治疗的女性(60%)，但联合治疗结束时的总有效率相同(75%)。在治疗失败的模式、中位反应持续时间和总存活率方面，两组之间没有显著差异。治疗不受绝经或雌激素受体状态的影响。手术组有2例在累积剂量小于500 mg/m2后出现阿霉素性心肌病。本研究的结果未能表明手术本身改善了包括局部控制在内的总体结果，而不是在综合治疗模式下的放射治疗。
In a prospective randomized study, the efficacy of two combined modality approaches (chemotherapy plus radiotherapy or chemotherapy plus mastectomy) was tested in a total of 132 women with locally advanced breast cancer. Chemotherapy consisted of Adriamycin plus vincristine (AV) administered for three cycles before either local-regional modality and subsequently for seven additional cycles. Although a higher proportion of women achieved complete remission after mastectomy (100%) compared to women given radiotherapy (60%), the total response rate at the end of combined modality was identical (75%). There was no significant difference between the two treatment groups in terms of patterns of treatment failure, median duration of response, and total survival. Treatment was not influenced by menopausal or estrogen receptor status. Two patients of the surgical group showed Adriamycin-induced cardiomyopathy after cumulative doses less than 500 mg/m2. The results of present study failed to indicate that surgery per se improved the overall results including local control, over radiotherapy in a combined modality setting.