Bio-Catalytic Bis-Michael Reaction for Generating Cyclohexanones with a Quaternary Carbon Center Using Glucoamylase
Bio-Catalytic Bis-Michael Reaction for Generating Cyclohexanones with a Quaternary Carbon Center Using Glucoamylase
复制标题
使用葡糖淀粉酶生物催化双迈克尔反应生成具有季碳中心的环己酮
DOI：
10.1007/s10562-016-1964-6
复制
发表时间：
2017
影响因子：
2.8
通讯作者：
Guan Zhi
中科院分区：
文献类型：
--
作者：
Zhang Yong;Li Rui;He Yan-Hong;Guan Zhi
报道了生物催化双Michael反应构筑季碳中心的研究。尼日尔曲霉葡萄糖淀粉酶（AnGA）是一种可持续发展的生态友好型催化剂。以92%的产率合成了各种高取代度的季碳中心反式环己酮。图摘要尼日尔曲霉葡萄糖淀粉酶（AnGA）催化（1 E，4 E）-1，5-二芳基-1，4-二烯-3-戊酮与活性亚甲基化合物的双Michael加成反应，生成了多种具有季碳中心的高度取代的反式环己酮
AbstractBio-catalytic bis-Michael reaction for the construction of quaternary carbon centers is reported. Glucoamylase fromAspergillus niger(AnGA) was used as a sustainable and eco-friendly catalyst. Various highly substitutedtrans-cyclohexanones with a quaternary carbon center were obtained with yields of up to 92%. As a novel case of enzyme promiscuity, this work provides a bio-catalytic alternative for construction of quaternary carbon centers.Graphical AbstractGlucoamylase fromAspergillus niger(AnGA) catalyzed the bis-Michael addition of (1E,4E)-1,5-diarylpenta-1,4-dien-3-ones with active methylene compounds to form various highly substitutedtrans-cyclohexanones with a quaternary carbon center