Quinone Methides: Photochemical Generation and its Application in Biomedicine
Quinone Methides: Photochemical Generation and its Application in Biomedicine
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DOI：
10.2174/138527281801140121122330
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发表时间：
2014-01-01
影响因子：
2.6
通讯作者：
Kralj, Marijeta
中科院分区：
文献类型：
--
作者：
Basaric, Nikola;Mlinaric-Majerski, Kata;Kralj, Marijeta
醌甲基化物是一类重要的酚类化学和生物化学中间体，具有广泛的生物活性。某些类别的抗癌抗生素由于使DNA烷基化的QM的代谢形成而表现出它们的作用。光化学反应提供了温和和简单的方法来量子阱。产生量子点的光反应包括氧杂杂环的裂解、脱卤化氢、脱水、脱氨、激发态分子内质子转移（ESIPT）和酚类的互变异构。这篇评论（137篇参考文献）以不同的光化学反应为特征，给出了适用于生物学和医学的量子力学。
Quinone methides (QMs) are important intermediates in chemistry and biochemistry of phenols that are characterized by wide biological activity. Some classes of anticancer antibiotics exhibit their effect due to methabolic formation of QMs that alkylate DNA. Photochemical reactions provide mild and easy approach to QMs. Photoreactions that give QMs include cleavage of oxa-heterocycles, dehydrohalogenation, dehydration, deammination, excited state intramolecular proton transfer (ESIPT) and tautomerizations of phenols. This critical review (137 references) features different photochemical reactions giving QMs that are applicable in biology and medicine.