STRETCH-INDUCED GROWTH IN CHICKEN WING MUSCLES - NEW MODEL OF STRETCH HYPERTROPHY
STRETCH-INDUCED GROWTH IN CHICKEN WING MUSCLES - NEW MODEL OF STRETCH HYPERTROPHY
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DOI：
10.1152/ajpcell.1980.238.1.c62
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
MOLE, PA
中科院分区：
文献类型：
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作者：
HOLLY, RG;BARNETT, JG;MOLE, PA
一种新的模型，拉伸诱导生长的评估在4个鸡翅膀肌肉拉伸到不同程度的弹簧加载的管状组件。肌肉的长度和横截面与它们被拉伸的程度成比例地增长。纵向增长基本上是在1周内完成，而肌肉增长的横截面通过至少5周的拉伸。肌肉既没有失去神经支配，也没有固定，通过EMG [肌电图]测量的肌肉活动没有增加。随着牵拉，阔筋膜肌（PAT）（一种抽搐肌）的氧化酶活性大幅增加，但缓慢紧张性前背阔肌（ALD）的氧化酶活性相对不变。拉伸改变了PAT中的线粒体酶比例，但在ALD中几乎没有影响。在PAT中，毛细血管密度随着拉伸而不变，但在ALD中降低。两块肌肉的毛细血管与纤维比率都增加了。肌肉生长和适应酶由于拉伸，但这些反应是不同的抽搐和紧张的肌肉。
A new model of stretch-induced growth is evaluated in 4 chicken wing muscles stretched to different extents by a spring-loaded tubular assembly. Muscles grew in length and cross section in proportion to the extent to which they were stretched. Longitudinal growth was essentially completed within 1 wk, while muscles grew in cross section through at least 5 wk of stretch. The muscles were neither denervated nor immobilized, and muscle activity as measured by EMG [electromyography] was not increased. Oxidative enzyme activities increased substantially with stretch in the patagialis (PAT), a twitch muscle, but were relatively unchanged in the slow-tonic anterior latissimus dorsi (ALD). Stretch altered mitochondrial enzyme proportions in the PAT, but had little effect in the ALD. Capillary density was unchanged with stretch in the PAT, but decreased in the ALD. Capillary-to-fiber ratio, increased in both muscles. Muscles grow and adapt enzymatically due to stretch, but these responses are dissimilar in twitch and tonic muscles.