A Polymethyl Methacrylate-Based Acrylic Dental Resin Surface Bound with a Photoreactive Polymer Inhibits Accumulation of Bacterial Plaque
A Polymethyl Methacrylate-Based Acrylic Dental Resin Surface Bound with a Photoreactive Polymer Inhibits Accumulation of Bacterial Plaque
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DOI：
10.11607/ijp.5332
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发表时间：
2017-11-01
影响因子：
2.3
通讯作者：
Baba, Kazuyoshi
中科院分区：
文献类型：
--
作者：
Fukunishi, Miya;Inoue, Yuuki;Baba, Kazuyoshi
用途：本研究的目的是检查聚（2-甲基丙烯酰氧基乙基磷酰胆碱-co-甲基丙烯酸正丁酯-co-2-甲基丙烯酰氧基乙氧基-p-叠氮基苯甲酸酯）（PMBPAz）涂层在聚甲基丙烯酸甲酯（PMMA）基牙科树脂上抑制菌斑形成的能力，以及聚合物对水浸泡和化学暴露的耐久性。材料与方法：通过X射线光电子能谱（XPS）和水中静态空气接触角的测量，证实了PMBPAz在PMMA表面上的成功应用。采用变形链球菌生物被膜形成试验评价其对菌斑的抗粘附作用。PMBPAz涂层的PMMA表面上的机械和化学耐久性进行了检查，分别使用浸泡和浸泡试验。结果如下：观察到PMBPAz处理的PMMA表面上的磷和氮原子以及亲水状态的XPS信号，表明聚合物在基底上的存在。与未经处理的表面相比，经处理的PMMA表面显示出对变形链球菌生物膜形成的显著抑制。PMBPAz涂层在水浸泡和化学暴露后得以保存。此外，与未进行水浸泡的处理过的PMMA样本相比，水浸泡没有降低处理过的PMMA抑制生物膜形成的能力。结论：这项研究表明，PMBPAz涂层可能代表一个有用的改性PMMA表面抑制义齿菌斑积累。
Purpose: The aim of this study was to examine the ability of a poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butylmethacrylate-co-2-methacryloyloxyethyloxy-p-azidobenzoate) (PMBPAz) coating on polymethyl methacrylate (PMMA)-based dental resin to inhibit bacterial plaque formation, as well as the polymer's durability against water soaking and chemical exposure. Materials and Methods: Successful application of PMBPAz on PMMA surfaces was confirmed by x-ray photoelectron spectroscopy (XPS) and measuring the static air contact angle in water. The anti-adhesive effects to bacterial plaque were evaluated using Streptococcus mutans biofilm formation assay. The mechanical and chemical durabilities of the PMBPAz coating on the PMMA surfaces were examined using soaking and immersion tests, respectively. Results: XPS signals for phosphorus and nitrogen atoms and hydrophilic status on PMMA surfaces treated with PMBPAz were observed, indicating the presence of the polymer on the substrates. The treated PMMA surfaces showed significant inhibition of S mutans biofilm formation compared to untreated surfaces. The PMBPAz coating was preserved after water soaking and chemical exposure. In addition, water soaking did not decrease the ability of treated PMMA to inhibit biofilm formation compared to treated PMMA specimens not subjected to water soaking. Conclusion: This study suggests that PMBPAz coating may represent a useful modification to PMMA surfaces for inhibiting denture plaque accumulation.