[Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies].
[Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies].
复制标题
[苯二氮卓类药物的消除半衰期与老年人跌倒之间的关联：观察研究的荟萃分析]。
DOI：
10.1248/yakushi.18-00156
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
K. Mihara
中科院分区：
文献类型：
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作者：
Chikako Masudo;Yukari Ogawa;Naomi Yamashita;K. Mihara
苯二氮卓受体激动剂（BZDRAs）与老年人福尔斯跌倒风险增加相关。然而，尚未阐明BZDRA的消除半衰期（t1/2）与苯二氮卓类（BZD）和非苯二氮卓类（Z药物）之间的差异之间的相关性。通过对观察性研究进行荟萃分析，我们比较了1）短效BZDRA（t12 <12 h）与长效BZDRA（t12 ≥12 h）和2）BZD与Z药物在老年患者中的福尔斯风险。数据来自MEDLINE、科克伦图书馆和Igaku Chuo Zasshi。我们的研究共纳入了来自12篇文章的13项观察性研究（短效BZDRA，n=12;长效BZDRA，n=9; BZD，n=13; Z药物，n=7）。使用短效BZDRA显著增加了福尔斯的风险[比值比（OR）（95%置信区间（CI））：2.00（1.46-2.73）]、长效BZDRA [OR（95%CI）：2.16（1.61-2.89）]、BZD [OR（95%CI）：1.67（1.31-2.13）]和Z-药物[OR（95%CI）：2.42（1.35-4.34）]与BZDRA非使用者的风险相比。老年患者中福尔斯的风险增加在各组中相似，与t1/2无关。这项研究表明，老年患者应避免使用所有BZDRA，包括Z药物。
Benzodiazepine receptor agonists (BZDRAs) have been associated with an increased risk of falls in the elderly. However, the association between the elimination half-life (t1/2) of BZDRAs and the difference between benzodiazepines (BZDs) and non-benzodiazepines (Z-drugs) has not been clarified. By conducting a meta-analysis of observational studies, we compared the risk of falls with respect to 1) short-acting BZDRAs (t1/2<12 h) vs. long-acting BZDRAs (t1/2≥12 h) and 2) BZDs vs. Z-drugs in elderly patients. Data were retrieved from MEDLINE, the Cochrane Library, and Igaku Chuo Zasshi. In total, 13 observational studies from 12 articles were included in our study (short-acting BZDRAs, n=12; long-acting BZDRAs, n=9; BZDs, n=13; Z-drugs, n=7). The risk of falls was significantly increased by the use of short-acting BZDRAs [Odds ratio (OR) (95% Confidence interval (CI)): 2.00 (1.46-2.73)], long-acting BZDRAs [OR (95%CI): 2.16 (1.61-2.89)], BZDs [OR (95%CI): 1.67 (1.31-2.13)], and Z-drugs [OR (95%CI): 2.42 (1.35-4.34)] compared to the risk in BZDRAs non-users. The increased risk of falls in elderly patients was similar in each group and unrelated to t1/2. This study suggested that all BZDRAs including Z-drugs should be avoided in elderly patients.