Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype
Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype
复制标题
DOI：
10.1016/j.biopsych.2005.12.022
复制
发表时间：
2006-10-01
影响因子：
10.6
通讯作者：
Hewitt, John K.
中科院分区：
文献类型：
--
作者：
Huizinga, David;Haberstick, Brett C.;Hewitt, John K.
背景资料：单胺氧化酶A（MAOA）的功能启动子多态性被认为是儿童期虐待与后来的青少年和成人反社会行为之间关系的调节因素。尽管广泛的兴趣在这一假设，结果仍然是混合的几次尝试在replication.Methods：回归为基础的分析进行了测试的基因型与环境的相互作用，使用自我报告的身体虐待和MAOA基因型预测以后的反社会行为和逮捕暴力的参与者在全国青年调查家庭研究。我们还研究了使用暴力受害的措施的相互作用。分析样本包括277名白人男性受访者，年龄在11-25岁，在1976年谁提供口腔拭子DNA样本，并成功地为可变数目串联重复序列（VNTR）在MAOA启动子使用polymerase chainreaction.Results：青少年时期的父母虐待是青少年和成人反社会和暴力相关的行为问题的危险因素。MAOA和MAOA-虐待相互作用的主效应检验不显著。使用的措施，青少年暴力victimination.Conclusions：从这个一般人群样本的调查结果不能证实的假设，MAOA缓和青少年虐待和青少年或成人反社会行为之间的关系。
Background: A functional promoter polymorphism in monoamine oxidase A (MAOA) has been implicated as a moderating factor in the relationship between childhood maltreatment and later adolescent and adult antisocial behavior. Despite wide interest in this hypothesis, results remain mixed from the few attempts at replication.Methods: Regression-based analyses were conducted to test for a genotype-environment interaction using self-reported physical abuse and MAOA genotype to predict later antisocial behavior and arrests for violence by participants in the National Youth Survey Family Study. We also examined the interaction using a measure of violent victimization. The analysis sample included 277 Caucasian male respondents, aged 11-25 in 1976 who provided buccal swab DNA samples and who were successfully genotyped for the variable number tandem repeat (VNTR) in the MAOA promoter using polymerase chain reaction.Results: Maltreatment by a parent during adolescence was a risk factor for adolescent and adult antisocial and violence related behavioral problems. Tests for the main effect of MAOA and a MAOA-maltreatment interaction were nonsignificant. Similar results were obtained using the measure of adolescent violent victimization.Conclusions: Findings from this general population sample could not confirm the hypothesis that MAOA moderates the relationship between adolescent maltreatment and adolescent or adult antisocial behavior.