CROSS-REACTIVITY BETWEEN QUINOLONES - REPORT OF 3 CASES
CROSS-REACTIVITY BETWEEN QUINOLONES - REPORT OF 3 CASES
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DOI：
10.1111/j.1398-9995.1993.tb02413.x
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发表时间：
1993-07-01
期刊：
影响因子：
12.4
通讯作者：
LAZARO, M
中科院分区：
文献类型：
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作者：
DAVILA, I;DIEZ, ML;LAZARO, M
喹诺酮类药物之间的交叉反应性不确定。最近，我们研究了三位疑似对喹诺酮类药物过敏的患者。我们对所有患者进行皮肤试验、组胺释放试验、RAST和口服喹诺酮类药物及另一种同代喹诺酮类药物。5名特应性和5名非特应性受试者作为对照。皮试、组胺释放试验、RAST均无诊断价值。通过口服可控刺激重现上述反应，所有患者均对另一种喹诺酮类药物产生反应。我们的结论是，喹诺酮类药物之间的交叉反应似乎是非常重要的，应该建议任何对其中一种药物有过敏反应的患者避免使用任何喹诺酮类药物。
Cross-reactivity between quinolones is uncertain. Recently, we studied three patients who had developed suspected allergic reactions to a quinolone. For all of them we performed skin test, histamine release test, RAST, and oral provocation with the suspected quinolone and also with another quinolone of the opposite generation. Five atopic and five nonatopic subjects were used as controls. Neither skin test, histamine release test, nor RAST was useful in the diagnosis. By means of oral controlled provocation, the reactions were reproduced, and all the patients also reacted to another quinolone. We concluded that cross-reactivity between quinolones seems to be very important, and avoidance of any quinolone should be recommended to any patient who has suffered an allergic reaction to one of these drugs.