The multifaceted role of pirfenidone and its novel targets.
The multifaceted role of pirfenidone and its novel targets.
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DOI：
10.1186/1755-1536-3-16
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Armendáriz-Borunda J
中科院分区：
文献类型：
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作者：
Macías-Barragán J;Sandoval-Rodríguez A;Navarro-Partida J;Armendáriz-Borunda J
吡非尼酮 (PFD) 是一种在多种体外和动物肺、肝和肾纤维化模型中表现出抗纤维化特性的分子。这些病理学与异常纤维伤口愈合过程共享许多纤维形成途径；因此，组织修复和组织再生调节机制发生改变。研究 PFD 作为抗纤维化药物在纤维化疾病临床和实验模型中的有用性。人们越来越了解 PFD 对伤口愈合机制的分子影响，从而产生了治疗肺、肝和肾组织纤维化的新方法。尽管纤维化的最佳治疗方法仍未确定，但包含吡非尼酮这种广泛应用的分子的联合治疗方案可能为纤维化疾病提供有效的治疗。
Pirfenidone (PFD) is a molecule that exhibits antifibrotic properties in a variety of in vitro and animal models of lung, liver and renal fibrosis. These pathologies share many fibrogenic pathways with an abnormal fibrous wound-healing process; consequently, tissue repair and tissue regeneration-regulating mechanisms are altered. To investigate the usefulness of PFD as an antifibrotic agent in clinical and experimental models of fibrotic disease. There is a growing understanding of the molecular effects of PFD on the wound healing mechanism, leading to novel approaches for the management of fibrosis in lung, liver and renal tissues. Although the optimum treatment for fibrosis remains undefined, it is possible that combined therapeutic regimens that include this wide-application molecule, pirfenidone, could offer a useful treatment for fibrotic disease.