Environmental risk factors for REM sleep behavior disorder A multicenter case-control study
Environmental risk factors for REM sleep behavior disorder A multicenter case-control study
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DOI：
10.1212/wnl.0b013e31825dd383
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发表时间：
2012-07-01
期刊：
影响因子：
9.9
通讯作者：
Wolfson, C.
中科院分区：
文献类型：
--
作者：
Postuma, R. B.;Montplaisir, J. Y.;Wolfson, C.
目的：特发性快速眼动睡眠行为障碍是一种以做梦为特征的睡眠异常，通常是帕金森综合征和痴呆的预诊断体征。由于危险因素尚未被定义，我们发起了一个多中心的病例对照研究，以评估环境和生活方式的危险因素REM睡眠behavior disorder.Methods：情况下，与特发性REM睡眠行为障碍的患者谁是免费的痴呆症和帕金森氏症，从13个国际REM睡眠行为障碍研究小组中心招募。对照组按年龄和性别配对。通过标准化问卷调查评估潜在的环境和生活方式风险因素。调整年龄，性别和中心的非条件Logistic回归进行调查的环境factors.Results：共694名参与者（347例患者，347名对照）被招募。在病例中，平均年龄为67.7 ± 9.6岁，81.0%为男性。病例更可能吸烟（曾经吸烟者= 64.0% vs 55.5%，调整后比值比[OR] = 1.43，p = 0.028）。咖啡因和酒精的使用在病例组和对照组之间没有差异。病例更可能报告既往头部损伤（19.3% vs 12.7%，OR = 1.59，p = 0.037）。受正规教育年限较少的病例（11.1 +/- 4.4年vs 12.7 +/- 4.3，p = 0.001），更有可能报告曾作为农民工作（19.7% vs 12.5% OR = 1.67，p = 0.022），焊接临界增加（17.8% vs 12.1%，OR = 1.53，p = 0.063）。结论：吸烟、颅脑损伤、农药暴露和农业耕作是特发性REM睡眠行为障碍的潜在危险因素。神经病学（R）2012;79：428-434
Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder.Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors.Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 +/- 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR = 1.59, p = 0.037). Cases had fewer years of formal schooling (11.1 +/- 4.4 years vs 12.7 +/- 4.3, p = 0.001), and were more likely to report having worked as farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008).Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder. Neurology (R) 2012;79: 428-434