AMYGDALOID INHIBITION OF MATERNAL-BEHAVIOR IN THE NULLIPAROUS FEMALE RAT
AMYGDALOID INHIBITION OF MATERNAL-BEHAVIOR IN THE NULLIPAROUS FEMALE RAT
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DOI：
10.1016/0031-9384(80)90377-7
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发表时间：
1980-01-01
影响因子：
2.9
通讯作者：
LUEBKE, C
中科院分区：
文献类型：
--
作者：
FLEMING, AS;VACCARINO, F;LUEBKE, C
研究了杏仁核病变的影响，其主要的传出投影系统，质状末端或其他非纤维化脑部位对无雌性大鼠孕产妇行为的诱导的影响。与对照动物相比，维持杏仁核或质子末端的病变的动物更快地变成了母体。在第二项研究中，研究了病变对杏仁核不同部分对母性和恐惧反应的影响。与维持基底外侧杏仁糖损伤或没有杏仁核损伤的动物相比，对皮质中的杏仁核的损害的动物更快地变成了母体。同样，与病变的对照相比，患有杏仁核病变的动物在许多恐惧介导的任务上的恐惧感减少了。这项第三项研究试图通过观察杏仁核或肌层末端病变的无效动物来与恐惧的反应性和母体行为相互联系，因为它们对每天放置在其首选的筑巢象限中的不熟悉的寄养幼犬的反应。尽管对照动物积极避免将幼崽放入其巢穴位置（通过将其巢部位移至笼子的另一个象限），但没有杏仁核病变的动物或肌层末端的病变。无效的女性通常不会对幼犬产生反应，因为这些雌性通常比专利女性更有土著，他们倾向于发现幼犬及其新型气味，这种异味厌恶。他们行为的这一方面可能是由杏仁核介导的。讨论了女性在分娩时通常表现出的快速母体反应能力。
The effects of lesions of the amygdala, its major efferent projection system, the stria terminalis or other non-limbic brain sites on the induction of maternal behavior in the nulliparous female rat were investigated. Animals sustaining lesions of either the amygdala or the stria terminalis became maternal more rapidly than did control animals. In a 2nd study, the effects of lesions to different portions of the amygdala on maternal and fear responding were investigated. Animals sustaining damage to the corticomedial amygdaloid nuclei became maternal more quickly than did animals sustaining either basolateral amygdaloid damage or no amygdaloid damage. Also in comparison to lesioned controls, animals with lesions of the amygdala showed reduced fearfulness on a number of fear-mediated tasks. The 3rd study attempted to interrelate fear responsiveness and maternal behavior by observing nulliparous animals with amygdaloid or stria terminalis lesions for their responses to unfamiliar foster pups placed daily into their preferred nesting quadrant. While control animals actively avoided pups placed into their nest sites (by moving their nest site to another quadrant of the cage), animals with amygdaloid lesions or lesions of the stria terminalis, did not. Nulliparous females generally do not respond maternally to pups because these females are, in general, more neophobic than paturient females and they tend to find pups and their novel odors, aversive. This aspect of their behavior is likely mediated by the amygdala. The rapid maternal responsiveness normally shown by the female at parturition was discussed.