Outcome in patients with idiopathic inflammatory myositis: morbidity and mortality
Outcome in patients with idiopathic inflammatory myositis: morbidity and mortality
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DOI：
10.1093/rheumatology/41.1.22
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发表时间：
2002-01-01
期刊：
影响因子：
5.5
通讯作者：
Isenberg, DA
中科院分区：
文献类型：
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作者：
Sultan, SM;Ioannou, Y;Isenberg, DA
目标。通过评估SF-36测量的健康状况和在一个风湿病中心20年随访期间的累积生存概率来评估46名特发性肌炎患者的长期预后。从我们的数据库中确定了从1978年到1999年长期随访的46名患者。所有患者都符合Bohan和Peter的肌炎标准中的四项标准中的三项。我们排除了与恶性肿瘤相关的疾病和包涵体肌炎。23例(50%)为成人起病的多发性肌炎，14例(30.4%)为成人起病的皮肌炎，1例为儿童期起病的皮肌炎，8例(17.4%)有重叠综合征(与系统性红斑狼疮或类风湿关节炎相关)。病程中完全缓解7例(15.2%)，单相疾病8例(17.4%)，复发缓解9例(19.6%)，慢性进展性疾病16例(34.8%)，死亡6例(13.04%)。与一般人群相比，所有患者在健康的各个方面的SF-36得分都显著降低(P<或等于0.001)。慢性进展性疾病患者的躯体疼痛(P<0.05，t检验)显著大于复发-缓解型患者，但在健康的其他方面没有差异。疾病活动期与非活动期患者SF-36各领域得分差异无统计学意义(P>0.05
Objective. To assess the long-term outcome of a cohort of 46 patients with idiopathic myositis by assessing both health status, as measured by the SF-36, and cumulative survival probability over a 20-yr follow-up period at a single rheumatology centre.Methods and results. Forty-six patients under long-term follow-up from 1978 to 1999 were identified from our database. All patients fulfilled three out of four of the Bohan and Peter criteria for myositis. We excluded those with malignancy-associated disease and those with inclusion body myositis. Twenty-three patients (50%) had adult-onset polymyositis, 14 (30.4%) had adult-onset dermatomyositis, one had childhood-onset dermatomyositis and eight (17.4%) had an overlap syndrome (associated with either systemic lupus erythematosus or rheumatoid arthritis). During the course of the disease, seven patients (15.2%) went into full remission, eight (17.4%) had monophasic illness, nine (19.6%) had a relapsing-remitting course, 16 (34.8%) had chronic progressive illness and six (13.04%) died. All patients had significantly lower SF-36 scores in all aspects of health compared with the general population (Pless than or equal to0.001). Patients with chronic progressive illness had significantly greater bodily pain (Pless than or equal to0.05, t-test) than those with a relapsing-remitting illness, but did not differ in other aspects of health. There was no significant difference in the scores in the different domains of the SF-36 between the patients with active disease and those with inactive disease (0.05