Expression profiling and lung cancer development.
Expression profiling and lung cancer development.
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DOI：
10.1513/pats.200607-143jg
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Powell, Charles A
中科院分区：
文献类型：
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作者：
Borczuk, Alain C;Powell, Charles A
最近的肺癌研究已经指向使用分子方法来促进早期诊断，以确定与组织学异质性相关的临床相关生物学因素，并确定新的治疗药物。这项研究利用了技术进步，允许快速高通量测定询问基因组，蛋白质组和表观基因组。在这篇综述中，我们将集中在肺上皮细胞的恶性转化和肺癌的分化和进展的理解的基因表达谱。这些研究提供了重要的信息，烟草烟雾相关的气道领域的致癌作用的基因组改变和介导肺肿瘤的侵袭和组织分化的发展途径，以响应损伤。
Recent lung cancer research has been directed to using molecular approaches to facilitate early diagnosis, to identify clinically relevant biological factors associated with histologic heterogeneity, and to identify novel therapeutic agents. This research takes advantage of technical advances that allow rapid high throughput assays to interrogate the genome, proteome, and epigenome. In this review of gene expression profiling in lung carcinogenesis, we will focus upon recent advances in the understanding of malignant transformation of lung epithelial cells and of lung cancer differentiation and progression. These studies have provided important information about the genomic alterations of tobacco smoke-associated airway field carcinogenesis and about the developmental pathways that mediate lung tumor invasion and histologic differentiation in response to injury.