Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses
Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses
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DOI：
10.1128/jvi.01046-15
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发表时间：
2015-08-01
影响因子：
5.4
通讯作者：
Kuhn, Jens H.
中科院分区：
文献类型：
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作者：
Lauck, Michael;Alkhovsky, Sergey V.;Kuhn, Jens H.
猿猴出血热（SHF）对猕猴是致命的。根据临床表现和血清学诊断，所有报告的SHF暴发被认为是由同一病毒的不同毒株引起的，猴出血热病毒（SHFV;动脉炎病毒科）。在这里，我们表明，SHF爆发在苏呼米在1964年和阿拉莫戈多在1989年引起的不是SHFV，而是由两种新的分歧动脉炎病毒。我们的研究结果表明，多种不同的猴动脉炎病毒可以导致SHF。
Simian hemorrhagic fever (SHF) is lethal for macaques. Based on clinical presentation and serological diagnosis, all reported SHF outbreaks were thought to be caused by different strains of the same virus, simian hemorrhagic fever virus (SHFV; Arteriviridae). Here we show that the SHF outbreaks in Sukhumi in 1964 and in Alamogordo in 1989 were caused not by SHFV but by two novel divergent arteriviruses. Our results indicate that multiple divergent simian arteriviruses can cause SHF.