Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population
Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population
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DOI：
10.1007/s10038-004-0225-5
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Bell, GI
中科院分区：
文献类型：
--
作者：
Iwasaki, N;Horikawa, Y;Bell, GI
编码半胱氨酸蛋白酶calpain-10的基因变异与2型糖尿病的风险有关。我们在对927例患者和929例对照者的汇总分析中，研究了钙蛋白酶-10基因的三种多态性（SNP-43、Indel-19和SNP-63）对日本人群2型糖尿病发展的影响。我们观察到SNP-43、Indel-19和SNP-63单独或作为单倍型与2型糖尿病风险改变无关，除了罕见的111/ 221单倍型（比值比（OR）= 3.53，P= 0.02）。然而，斯特拉蒂。基于合并研究人群（< 50岁和≥50岁）中位诊断年龄的阳离子显示，Indel-19的等位基因2和121单倍型与诊断年龄较晚的患者的风险降低相关（诊断年龄≥ 50岁OR分别为0.82和0.80; P = 0.04和0.02）。因此，calpain-10基因的变异可能会影响日本人患2型糖尿病的风险，特别是在老年人中。
Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/ 221 haplogenotype ( odds ratio ( OR) = 3.53, P= 0.02). However, strati. cation based on the median age-at-diagnosis in the pooled study population (< 50 and ≥50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis ≥ 50 years OR = 0.82 and 0.80, respectively; P = 0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.