ON STRUCTURE OF CARDIOLIPIN
ON STRUCTURE OF CARDIOLIPIN
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DOI：
10.1021/bi00895a023
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发表时间：
1964-01-01
期刊：
影响因子：
2.9
通讯作者：
BALLOU, CE
中科院分区：
文献类型：
--
作者：
LECOCQ, J;BALLOU, CE
牛心和草分枝杆菌的心磷脂（二羟磷脂酰甘油）在偏高碘酸钠和1，1-二甲基肼的作用下脱酰并降解为甘油-1，3-二磷酸。结果表明，脂质具有1，3-二磷脂酰甘油结构，这一点仍有待商榷。作为参考，已经制备了甘油-1，3-二磷酸和L-甘油-1，2-二磷酸的结晶环己胺盐。通过心磷脂的脱酰作用获得的胆甾醇二磷酸的报道的旋光活性已经得到证实，并且发现与P. Plackett合成的合成1，3-二-O-（L-甘油-3 [图像]-磷酰基）-甘油的旋光活性相同（Australian J.Chem.17，101，1964），从而建立了心磷脂分子的全部绝对构型。
Cardiolipin (diphos-phatidylglycerol) from beef heart and from Mycobacterium phlei has been deacylated and degraded to glycerol-l,3-diphosphate by the action of sodium metaperiodate and 1,1-dimethylhydrazine. The results establish that the lipid has the 1,3-diphosphatidyl-glycerol structure, a point that was still open to question. For references, crystalline cyclo-hexylamine salts of glycerol-l,3-diphosphate and L-glycerol-1,2-diphosphate have been prepared. The reported optical activity of the triglyceroldiphosphate obtained by deacylation of cardiolipin has been confirmed, and is found to be identical with that of synthetic 1,3-di-O-(L-glycerol-3[image]-phosphoryl)-glycerol synthesized by P. Plackett (Australian J. Chem. 17, 101, 1964), thus establishing the over-all absolute configuration of the cardiolipin molecule.