Gene expression in hippocampal long-term potentiation
Gene expression in hippocampal long-term potentiation
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DOI：
10.1177/107385849900500512
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发表时间：
1999-09-01
期刊：
影响因子：
5.6
通讯作者：
Fields, RD
中科院分区：
文献类型：
--
作者：
Dudek, SM;Fields, RD
海马LTP最近的工作集中在高频刺激诱导的基因表达，以及负责这些基因的诱导的信号转导级联。LTP持续超过5小时的许多情况包括以下过程中的一些或全部：1）标记增强的突触，可能通过磷酸化; 2）向细胞核发出信号; 3）细胞核中的激酶级联和转录因子; 4）立即早期基因和/或突触蛋白的表达;最后，5）将新合成的蛋白质（或RNA）靶向增强的突触，而不是靶向未增强的突触）。不幸的是，目前大多数针对LTP晚期表达提出的方案仍然是高度推测性的。一个关键的审查有关的基因表达在海马LTP的作用和最近的工作对这个问题的讨论的文献。
Recent work on hippocampal LTP has focused on gene expression induced with high-frequency stimulation, as well as the signal transduction cascades responsible for the induction of these genes. Many scenarios for LTP lasting for greater than 5 hours include some or all of the following processes: 1) tagging of potentiated synapses, possibly by phosphorylation; 2) signaling to the nucleus; 3) kinase cascades and transcription factors in the nucleus; 4) expression of immediate-early genes and/or synaptic proteins; and, finally, 5) targeting of newly synthesized proteins (or RNAs) to the potentiated synapses land not to the unpotentiated synapses). Unfortunately, most scenarios proposed for the late-phase expression of LTP are still highly speculative at this time. A critical review of the literature relating to the role of gene expression in hippocampal LTP and a discussion of recent work on the subject will be presented.