The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
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pre-miRNA 的两种多态性与乳腺癌风险之间的关联：荟萃分析
DOI：
10.1007/s10549-010-0993-x
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发表时间：
2011-01-01
影响因子：
3.8
通讯作者：
Zhang, Lin
中科院分区：
文献类型：
--
作者：
Gao, Lin-Bo;Bai, Peng;Zhang, Lin
越来越多的证据表明，mirna作为肿瘤抑制因子或致癌基因参与人类癌变。位于pre-miRNA中的单核苷酸多态性（Single nucleotide polymorphism， SNP）可能影响miRNA的加工，进而影响成熟miRNA的表达。关于前mirna的两种常见多态性（即hsa-miR-146 rs2910164和hsa-miR-196a2 rs11614913）与乳腺癌的关联，先前的研究得出了相互矛盾的结果。为了获得这些多态性与乳腺癌风险之间更精确的关联，我们进行了一项荟萃分析。通过检索PubMed截至2010年5月的数据，共发现了4项研究，其中has-miR-146a rs2910164多态性为3,007例和3,718例对照，hsa-miR-196a2 rs11614913多态性为3,287例和4,298例对照。我们发现，在纯合子比较（OR = 1.30; 95% CI, 1.01-1.68）和显性模型（OR = 1.11; 95% CI, 1.01-1.23）中，携带has-miR-196a2 rs11614913多态性CC基因型的个体与乳腺癌风险增加相关。然而，在所有测试的比较模型中，未观察到has-miR-146a rs2910164多态性与乳腺癌风险之间的显著关联。这些发现表明has-miR-196a2 rs11614913多态性可能在乳腺癌的发展中起关键作用。
Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and then influence the expression of mature miRNA. Previous studies yielded conflicting results as to the association of two common polymorphisms in pre-miRNAs (i.e. hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913) with breast cancer. To derive a more precise effect on the association between these polymorphisms and breast cancer risk, we conducted a meta-analysis. Through retrieving PubMed for the period up to May 2010, a total of four studies were identified with 3,007 cases and 3,718 controls for has-miR-146a rs2910164 polymorphism and with 3,287 cases and 4,298 controls for hsa-miR-196a2 rs11614913 polymorphism. We found that individuals carrying CC genotype of has-miR-196a2 rs11614913 polymorphism was associated with an increased breast cancer risk in homozygote comparison (OR = 1.30; 95% CI, 1.01-1.68), and dominant model (OR = 1.11; 95% CI, 1.01-1.23). However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested. These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development.