PHARMACOKINETICS OF CAPACITY-LIMITED SYSTEMS
PHARMACOKINETICS OF CAPACITY-LIMITED SYSTEMS
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DOI：
10.1002/j.1552-4604.1989.tb03369.x
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发表时间：
1989-06-01
影响因子：
2.9
通讯作者：
JUSKO, WJ
中科院分区：
文献类型：
--
作者：
JUSKO, WJ
非线性在药代动力学中是常见的，并且最经常发生是因为可用于与相对高浓度的药物相互作用的生物材料的浓度有限。Michaelis-Menten型函数可应用于显示容量限制的代谢、运输和结合现象。非线性系统可以用微分方程（直接或转换为线性形式），积分方程（非封闭形式）或相对较新的面积/矩或MRT关系来处理。药物处置研究应包括几个剂量水平，并提供建议，用于检测典型实验数据中一个或多个非线性吸收或处置过程的存在。
Nonlinearities are commonplace in pharmacokinetics and most frequently occur because of a limited concentration of biological material available for interaction with relatively high concentrations of drugs. The Michaelis-Menten-type function can be applied to metabolism, transport, and binding phenomena that display capacity-limitation. Nonlinear systems can be handled with differential equations (directly or converted to linear form), integrated equations (in non-closed form) or with relatively new area/moment or MRT relationships. Drug disposition studies should include several dose levels and recommendations are provided for detecting the presence of one or more nonlinear absorption or disposition processes in typical experimental data.