Axonal loss results in spinal-cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis
Axonal loss results in spinal-cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis
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DOI：
10.1093/brain/123.3.519
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发表时间：
2000-03-01
期刊：
影响因子：
14.5
通讯作者：
Rodriguez, M
中科院分区：
文献类型：
--
作者：
McGavern, DB;Murray, PD;Rodriguez, M
最近的病理学研究再次强调多发性硬化症患者存在轴突损伤，多发性硬化症是人类最常见的中枢神经系统脱髓鞘疾病。然而，多发性硬化症患者脱髓鞘和轴突丧失的时间特征及其对临床和电生理异常的独立贡献尚不完全清楚。在这项研究中，我们使用进行性中枢神经系统炎性脱髓鞘的泰勒氏鼠脑脊髓炎病毒模型来证明脊髓中的脱髓鞘程度随后导致中到大的有髓纤维的损失。通过测量脊髓面积、运动诱发电位以及运动协调和平衡，我们确定脱髓鞘之后的轴突损失与电生理异常相关，并与运动协调性降低和脊髓萎缩密切相关。研究结果表明，中枢神经系统中原发性免疫介导的脱髓鞘可能导致轴突丧失，并且轴突丧失的严重程度与脊髓萎缩和神经缺陷的程度几乎完全相关。
Recent pathological studies have re-emphasized that axonal injury is present in patients with multiple sclerosis, the most common demyelinating disease of the CNS in humans, However, the temporal profile of demyelination and axonal-loss in multiple sclerosis patients and their independent contributions to clinical and electrophysiological abnormalities are not completely understood. In this study, we used the Theiler's murine encephalomyelitis virus model of progressive CNS inflammatory demyelination to demonstrate mar demyelination in the spinal cord is followed by a loss of medium to large myelinated fibres, By measuring spinal cord areas, motor-evoked potentials, and motor coordination and balance, we determined that axonal loss following,demyelination was associated with electro-physiological abnormalities and correlated strongly with reduced motor coordination and spinal cord atrophy, These findings demonstrate that axonal loss can follow primary, immune-mediated demyelination in the CNS and that the severity of axonal loss correlates almost perfectly with the degree of spinal cord atrophy and neurological deficits.