Transdermal Clonidine Skin Reactions
Transdermal Clonidine Skin Reactions
复制标题
透皮可乐定皮肤反应
DOI：
10.1111/j.1524-6175.2001.00954.x
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
L. Prisant
中科院分区：
文献类型：
--
作者：
L. Prisant
可乐定透皮治疗系统正被用作治疗血压的一种方法。全身副作用似乎比口服可乐定要少。然而，局部皮肤反应频繁发生，发生率随着使用剂量和使用时间的延长而增加。常见的体征包括红斑、结垢、水泡形成、划痕和硬化。过敏性接触性皮炎不太常见，但很常见。色素沉着和脱色也会发生。用0.5%氢化可的松预处理与皮肤刺激性减少和血液水平升高有关。虽然口服可乐定不再广泛用于高血压的治疗，但了解这种药物经皮给药的反应是很重要的。
The clonidine transdermal therapeutic system is being used as a therapy for blood pressure treatment. Systemic side effects seem to be fewer than with oral clonidine. However, localized skin reactions occur frequently and the incidence increases with the dose and duration of use. Common signs include erythema, scaling, vesiculation, excoriation, and induration. Allergic contact dermatitis is less frequent but common. Hyperpigmentation and depigmentation also occur. Pretreatment with 0.5% hydrocortisone is associated with less skin irritation and higher blood levels. Although oral clonidine is no longer widely used in the management of hypertension, awareness of these reactions to the transdermal delivery of this agent is important.