Dinucleotide repeat polymorphism at the human cardiac beta-myosin heavy chain gene (HMSYHCO1) locus.
Dinucleotide repeat polymorphism at the human cardiac beta-myosin heavy chain gene (HMSYHCO1) locus.
复制标题
人心脏 β-肌球蛋白重链基因 (HMSYHCO1) 基因座的二核苷酸重复多态性。
DOI：
10.1093/hmg/1.2.136
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发表时间：
1992
影响因子：
3.5
通讯作者：
Donis-Keller,H
中科院分区：
文献类型：
--
作者：
Warlick,CA;Ramachandra,S;Mishra,S;Donis-Keller,H
来源/描述：通过搜索已公布的序列(1)，在人类心脏/3-肌球蛋白重链基因（HMSYHCO1）的第24外显子下游约60 bp处发现了一个二核苷酸重复（TG） 23w。X52889)。由此产生的STS， sCAW2，被发现在高加索CEPH参考家系中检测多态性。这一新检测到的多态性包含15个等位基因，其信息量明显高于先前描述的位于sCAW2上游11.8 kb的二核苷酸重复多态性（6个等位基因，Het 66%; 2）。
Source/Description: A dinucleotide repeat (TG) 23w as identified approximately 60 bp downstream from exon 24 of the human cardiac/3-myosin heavy chain gene (HMSYHCO1) through a search of the published sequence (1)(GenBank accession no. X52889). The resulting STS, sCAW2, was found to detect a polymorphism in the Caucasian CEPH reference pedigrees. This newly detected polymorphism has 15 alleles and significantly higher informativeness than a previously described dinucleotide repeat polymorphism located 11.8 kb upstream from sCAW2 (6 alleles, Het 66%; 2).