Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells
Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells
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DOI：
10.1089/scd.2011.0512
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发表时间：
2012-04-01
影响因子：
4
通讯作者：
Broxmeyer, Hal E.
中科院分区：
文献类型：
--
作者：
Liu, Ying;Lee, Man-Ryul;Broxmeyer, Hal E.
HIV-1 tat相互作用蛋白110kda [Tip110；p110(nrb)/SART3/p110]是一种RNA结合核蛋白，参与调控HIV-1基因和宿主基因转录、mrna前剪接和癌症免疫学。最近，我们证明了Tip110在造血调节中的作用。在这里，我们发现TIP110也在人胚胎干细胞（hESCs）中表达，并且随着这些胚胎干细胞的分化表达减少。研究发现，通过上调和下调TIP110的表达，TIP110在维持多能因子（NANOG、OCT4和SOX2）在hESCs中的表达和多能性中起重要作用，尽管其机制以及TIP110是否直接起作用仍有待确定。
HIV-1 Tat-interacting protein of 110 kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up-and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.