Is the Mole Rat Vomeronasal Organ Functional?
Is the Mole Rat Vomeronasal Organ Functional?
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DOI：
10.1002/ar.24060
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发表时间：
2020-02-01
影响因子：
2
通讯作者：
Morrison, Edward E.
中科院分区：
文献类型：
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作者：
Dennis, John C.;Stilwell, Natalie K.;Morrison, Edward E.
裸鼹鼠（英语：Heterocephalus glaber）是一种生活在地下的啮齿类动物。螺杆犁鼻器神经上皮（VNE）显示出生后很少生长。然而，VNE仍然是神经元的一些哺乳动物，拥有非功能性犁鼻器官残余，例如，卡他鼻灵长类动物和一些蝙蝠。在此，我们描述了裸鼹鼠犁鼻器（VNO）的显微解剖，并进行了初步观察，以确定是否H。glaber与其他非洲鼹鼠分享了其最小的出生后VNE生长。我们还确定了免疫反应的有丝分裂标记Ki 67，生长相关蛋白43（GAP 43），和嗅觉标记蛋白（OMP）在六个成年和三个亚成年H。更光滑的个体。小样本的Cryptomys hottentotus和damarensis的VNE体积测量表明，这些非洲鼹鼠物种的VNE也可能是生长缺陷。Ki 67（+）细胞显示感觉上皮细胞有丝分裂活跃。GAP 43标记表明存在神经发生和OMP（+）细胞，尽管与GAP 43（+）细胞相比数量较少。在这方面，H. glaber没有出现退化。非洲鼹鼠VNE可能是异常的变量，也许反映了犁鼻系统的选择压力降低。如果是这样的话，非洲鼹鼠可能提供一个有用的遗传模型，了解在哺乳动物VNO观察到的形态变异。Anat Rec，2019年。(c)2019 Wiley Periodicals，Inc. Anat Rec，303：318-329，2020。(c)2019年美国解剖学协会
The colonial naked mole rat Heterocephalus glaber is a subterranean, eusocial rodent. The H. glaber vomeronasal organ neuroepithelium (VNE) displays little postnatal growth. However, the VNE remains neuronal in contrast to some mammals that possess nonfunctional vomeronasal organ remnants, for example, catarrhine primates and some bats. Here, we describe the vomeronasal organ (VNO) microanatomy in the naked mole rat and we make preliminary observations to determine if H. glaber shares its minimal postnatal VNE growth with other African mole rats. We also determine the immunoreactivity to the mitotic marker Ki67, growth-associated protein 43 (GAP43), and olfactory marker protein (OMP) in six adult and three subadult H. glaber individuals. VNE volume measurements on a small sample of Cryptomys hottentotus and Fukomys damarensis indicate that the VNE of those African mole rat species are also likely to be growth-deficient. Ki67(+) cells show that the sensory epithelium is mitotically active. GAP43 labelling indicates neurogenesis and OMP(+) cells are present though less numerous compared to GAP43(+) cells. In this respect, the VNO of H. glaber does not appear vestigial. The African mole rat VNE may be unusually variable, perhaps reflecting reduced selection pressure on the vomeronasal system. If so, African mole rats may provide a useful genetic model for understanding the morphological variability observed in the mammalian VNO. Anat Rec, 2019. (c) 2019 Wiley Periodicals, Inc. Anat Rec, 303:318-329, 2020. (c) 2019 American Association for Anatomy