Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study.
Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study.
复制标题
早期年龄相关性黄斑变性与脑部 MRI 变化有关吗？
DOI：
10.1016/j.ajo.2006.07.040
复制
发表时间：
2007
影响因子：
4.2
通讯作者：
AtherosclerosisRiskinCommunitiesStudy
中科院分区：
文献类型：
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作者：
Grosso,Andrea;Mosley,ThomasH;Klein,Ronald;Couper,DavidJ;Tikellis,Gabriella;Wong,TienY;AtherosclerosisRiskinCommunitiesStudy
目的探讨早期年龄相关性黄斑变性（AMD）与脑磁共振成像（MRI）改变的关系。方法：以人群为基础的横断面研究。根据白色病变（WML）、脑沟增宽（SW）和脑室扩大（VE）的严重程度对MRI扫描进行分级。根据视网膜照片对AMD进行分级。根据年龄、性别、种族或中心进行调整后，（5.0%的参与者）与WML无显著相关性（比值比[OR] 1.0，95%置信区间[CI]，0.6 - 1.6），SW（OR 0.6，95% CI，0.4 - 1.2）或VE（OR 1.0，95%CI 0.6 ~ 1.8）。结论这些数据显示早期AMD与脑MRI改变无统计学显著相关性，但该研究受限于CI较宽的少数病例。进一步的研究可能会澄清这些关联。
PURPOSETo examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes.DESIGNPopulation-based, cross-sectional study.METHODSA sample of 1,684 persons ages 51 to 72 years with no history of stroke had cerebral MRI and retinal photography. MRI scans were graded for severity of white matter lesions (WML), sulcal widening (SW), and ventricular enlargement (VE). AMD was graded from retinal photographs.RESULTSAfter adjustment for age, gender, race, or center, early AMD (5.0% of participants) was not significantly associated with WML (odds ratio [OR] 1.0, 95% confidence intervals [CI], 0.6 to 1.6), SW (OR 0.6, 95% CI, 0.4 to 1.2), or VE (OR 1.0, 95% CI, 0.6 to 1.8).CONCLUSIONSThese data showed no statistically significant association of early AMD with cerebral MRI changes, but the study was limited by a small number of cases with wide CIs. Further studies may clarify these associations.