Iodine Quantification With Dual-Energy CT: Phantom Study and Preliminary Experience With Renal Masses
Iodine Quantification With Dual-Energy CT: Phantom Study and Preliminary Experience With Renal Masses
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DOI：
10.2214/ajr.10.5541
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发表时间：
2011-06-01
影响因子：
5
通讯作者：
Macari, Michael
中科院分区：
文献类型：
--
作者：
Chandarana, Hersh;Megibow, Alec J.;Macari, Michael
OBJECTIVE.本研究的目的是验证双源双能量MDCT在定量体模和肾脏肿块中碘浓度方面的实用性。用双源双能量MDCT对一系列含有不同碘浓度溶液的试管进行成像。计算碘浓度并与已知碘浓度进行比较。15例肾脏病变患者的单期对比增强双源双能量MDCT数据由两名阅片师独立评估。双能量后处理用于生成仅含碘的图像。将感兴趣区域放置在病变上方的碘图像上，并作为参考，放置在主动脉上方，以记录病变和主动脉中的碘浓度。另一位放射科医生通过比较真正的非增强图像和对比增强图像来确定病变增强。采用基于秩的混合模型方差分析比较病变类型（单纯性囊肿、出血性囊肿、增强肿块）的病变碘浓度和病变与主动脉碘比值。在体模研究中，计算的碘浓度与真实碘浓度之间具有良好的相关性（R（2）= 0.998，p < 0.0001）。在患者研究中，15名患者中有13个非增强（10个单纯囊肿和3个高密度囊肿）和8个增强肾肿块。强化肿块的病灶碘浓度和病灶与主动脉碘比值明显高于高密度和单纯囊肿（p < 0.0001）。双源双能量MDCT的碘定量在体模中是准确的，可用于确定肾脏病变中碘的存在和浓度。肾脏肿块的特征可能是可能的，与一个单一的双源双能量MDCT采集没有增强图像或依赖于衰减测量的变化。
OBJECTIVE. The purpose of this study was to validate the utility of dual-source dual-energy MDCT in quantifying iodine concentration in a phantom and in renal masses.MATERIALS AND METHODS. A series of tubes containing solutions of varying iodine concentration were imaged with dual-source dual-energy MDCT. Iodine concentration was calculated and compared with known iodine concentration. Single-phase contrast-enhanced dual-source dual-energy MDCT data on 15 patients with renal lesions then were assessed independently by two readers. Dual-energy postprocessing was used to generate iodine-only images. Regions of interest were placed on the iodine image over the lesion and, as a reference, over the aorta, for recording of iodine concentration in the lesion and in the aorta. Another radiologist determined lesion enhancement by comparing truly unenhanced with contrast-enhanced images. Mixed-model analysis of variance based on ranks was used to compare lesion types (simple cyst, hemorrhagic cyst, enhancing mass) in terms of lesion iodine concentration and lesion-to-aorta iodine ratio.RESULTS. In the phantom study, there was excellent correlation between calculated and true iodine concentration (R(2) = 0.998, p < 0.0001). In the patient study, 13 nonenhancing (10 simple and three hyperdense cysts) and eight enhancing renal masses were evaluated in 15 patients. The lesion iodine concentration and lesion-to-aorta iodine ratio in enhancing masses were significantly higher than in hyperdense and simple cysts (p < 0.0001).CONCLUSION. Iodine quantification with dual-source dual-energy MDCT is accurate in a phantom and can be used to determine the presence and concentration of iodine in a renal lesion. Characterization of renal masses may be possible with a single dual-source dual-energy MDCT acquisition without unenhanced images or reliance on a change in attenuation measurements.