Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol).
Insulin action and dynamics modelled in patients taking the anabolic steroid methandienone (Dianabol).
复制标题
对服用合成代谢类固醇大力补 (Dianabol) 的患者进行胰岛素作用和动力学建模。
作者：
I. Godsland;N. Shennan;V. Wynn
在口服（OGTT）和静脉内（IVGTT）葡萄糖耐量试验期间测量血浆葡萄糖和胰岛素浓度在9名患者关闭和治疗与合成代谢类固醇，methandienone（大力补）.治疗期间，耐受性试验显示胰岛素反应显著增加，伴有葡萄糖耐量受损，通常归因于胰岛素抵抗的特征。然而，空腹血糖（FPG）和胰岛素（FPI）浓度显著降低，而通常与胰岛素抵抗相关的模式是两者都升高。IVGTT葡萄糖和胰岛素谱分析使用的算法来自最小模型的葡萄糖和胰岛素动力学最初由R。伯格曼和他的同事因此获得以下参数的测量值：Si，葡萄糖处理对胰岛素的敏感性; Sg，净胰岛素非依赖性葡萄糖处理; phi 1，在胰岛素分泌的第一阶段期间递送的胰岛素相对于高于模型导出的阈值的葡萄糖浓度的初始增加的积分浓度; φ 2，胰岛素分泌的第二阶段中胰岛素浓度的上升速率对高于模型导出的阈值的葡萄糖浓度的灵敏度;和tau 1/2，胰岛素半衰期。治疗后S1显著降低4倍。Sg，phi 1，phi 2和tau 1/2均显著升高，kappa显著降低。Sg和phi 1的增加均与治疗期间体重的增加显著相关。FPG和FPI的降低可以通过Sg增加和Dianabol诱导的对胰高血糖素的抗性的联合作用来解释。（250字处删节）
Plasma glucose and insulin concentrations were measured during oral (OGTT) and intravenous (IVGTT) glucose tolerance tests in nine patients off- and on-treatment with the anabolic steroid, methandienone (Dianabol). On-treatment, the tolerance tests showed a markedly increased insulin response accompanied by impairment of glucose tolerance, characteristics normally attributed to insulin resistance. However, fasting plasma glucose (FPG) and insulin (FPI) concentrations were significantly reduced, whereas the pattern normally associated with insulin resistance is for both to be raised. IVGTT glucose and insulin profiles were analysed using an algorithm derived from the minimal models of glucose and insulin dynamics originally proposed by R. Bergman and co-workers. Measures for the following parameters were thus obtained: Si, the sensitivity of glucose disposal to insulin; Sg, net insulin independent glucose disposal; phi 1, the integral concentration of insulin delivered during the first phase of insulin secretion relative to the initial increase in glucose concentration above a model-derived threshold; phi 2, the sensitivity of the rate of rise of insulin concentration in the second phase of insulin secretion to the concentration of glucose above a model-derived threshold; kappa, the fractional clearance rate of insulin; and tau 1/2, the insulin half-life. S1 was significantly reduced on treatment by a factor of 4. Sg, phi 1, phi 2 and tau 1/2 were all significantly increased, and kappa was significantly reduced. The increases in Sg and phi 1 both showed significant correlations with the increase in weight on-treatment. The reduction in FPG and FPI can be explained by the combined effects of the increase in Sg and Dianabol-induced resistance to glucagon.(ABSTRACT TRUNCATED AT 250 WORDS)