Changes in body water compartments with diuretic therapy in infants with chronic lung disease
Changes in body water compartments with diuretic therapy in infants with chronic lung disease
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DOI：
10.1016/s0378-3782(96)01841-5
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发表时间：
1997-04-25
影响因子：
2.5
通讯作者：
Bell, EF
中科院分区：
文献类型：
--
作者：
Segar, JL;Chemtob, S;Bell, EF
在患有慢性肺病的早产儿中研究了利尿疗法对体内水室的影响。婴儿的胎龄为 24 至 28 周，而研究时的中位产后年龄为 40 天。婴儿随机接受单独服用呋塞米（1.0 毫克/公斤/天）（n = 5）或联合美托拉宗（0.2 毫克/公斤/天，n = 7），连续 4 天。两组治疗后细胞外水 (ECW) 均显着下降 (P < 0.05)，但血浆容量、体内水分或体重没有变化。速尿组 ECW 的降低（503 +/- 28 至 446 +/- 19 ml/kg 初始体重）与速尿加美托拉宗联合用药（522 +/- 30 至 454 +/- 15 ml/kg 初始体重）的程度相似。两组的水和电解质摄入量相似，并且在研究过程中没有变化。这些发现表明，在患有慢性肺病的婴儿中，利尿疗法会引起体内水分的间室转移，最终减少间质水分，同时保持肺活量。只有呋塞米加美托拉宗联合治疗才能显着增加尿量，证实联合治疗在诱导利尿方面的功效增强。 (C) 1997 爱思唯尔科学爱尔兰有限公司
The effects of diuretic therapy on body water compartments were studied in preterm infants with chronic lung disease. Gestational age of the infants ranged from 24 to 28 weeks, while the median postnatal age at the time of study was 40 days. Infants were randomized to receive furosemide (1.0 mg/kg/day) alone (n = 5) or combined with metolazone (0.2 mg/kg/day, n = 7) for 4 consecutive days. Treatment in both groups produced a significant decrease (P < 0.05) in extracellular water (ECW) without changes in plasma volume, total body water or body weight. The decrease in ECW with furosemide (503 +/- 28 to 446 +/- 19 ml/kg initial body weight) was of similar magnitude to that seen with combined furosemide plus metolazone (522 +/- 30 to 454 +/- 15 ml/kg initial body weight). Water and electrolyte intakes were similar in both groups and unchanged over the course of the study. These findings suggest that in infants with chronic lung disease, diuretic therapy induces intercompartmental shifts in body water, ultimately decreasing interstitial water while preserving PV. Only combined treatment with furosemide plus metolazone produced a significant increase in urine output, confirming the increased efficacy of combination therapy in inducing diuresis. (C) 1997 Elsevier Science Ireland Ltd.