The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture
The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture
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DOI：
10.1073/pnas.0701214104
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发表时间：
2007-05-29
影响因子：
11.1
通讯作者：
Mittenthal, Jay E.
中科院分区：
文献类型：
--
作者：
Caetano-Anolles, Gustavo;Kim, Hee Shin;Mittenthal, Jay E.
代谢代表了酶促反应和转运过程的复杂集合，这些过程将代谢物转化为能够支持细胞生命的分子。在这里，我们探索现代新陈代谢的起源和演变。利用与代谢酶结构相关的基因组信息，我们整理了招募过程，发现大多数酶活性与9种最古老和分布最广泛的蛋白质折叠结构相关。对新发现功能的分析表明，酶的多样化发生在现代蛋白质世界开始的早期。最重要的是，系统发育重建的练习和其他证据强烈表明，代谢起源于酶与P-环水解酶折叠核苷酸代谢，可能在连接到嘌呤代谢子网络的途径。因此，第一个酶接管古代生物化学或益生元化学与RNA世界的核苷酸合成有关。
Metabolism represents a complex collection of enzymatic reactions and transport processes that convert metabolites into molecules capable of supporting cellular life. Here we explore the origins and evolution of modern metabolism. Using phylogenomic information linked to the structure of metabolic enzymes, we sort out recruitment processes and discover that most enzymatic activities were associated with the nine most ancient and widely distributed protein fold architectures. An analysis of newly discovered functions showed enzymatic diversification occurred early, during the onset of the modern protein world. Most importantly, phylogenetic reconstruction exercises and other evidence suggest strongly that metabolism originated in enzymes with the P-loop hydrolase fold in nucleotide metabolism, probably in pathways linked to the purine metabolic subnetwork. Consequently, the first enzymatic takeover of an ancient biochemistry or prebiotic chemistry was related to the synthesis of nucleotides for the RNA world.