Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging.
Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging.
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Nobiletin：针对昼夜节律网络促进生物能量学和健康老龄化。
DOI：
10.1134/s000629792012007x
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Mileykovskaya E;Yoo SH;Dowhan W;Chen Z
生物钟是一天中控制身体过程有序执行的生物学主谋。近年来，一个新兴的广泛关注的话题是生物钟调节剂，包括来自合成和天然来源的小分子，以及它们在疾病模型中的潜在应用。Nobiletin是一种天然存在的黄酮类化合物，在柑橘皮中含量最高。大量研究表明，Nobiletin具有广泛的生物活性，但其作用机制尚不清楚。我们最近发现，通过无偏见的化学筛选，Nobiletin影响生物钟机制，激活细胞内和整个身体下游过程的时间控制。使用疾病和衰老的动物模型，我们和其他人说明了Nobiletin对外周和大脑细胞能量学的有效有益作用，以促进健康衰老。鉴于其优异的安全性，Nobiletin可能是一种有前途的候选分子，用于针对慢性和年龄相关的神经退行性疾病的营养药物和慢性药物开发。
The circadian clock is the biological mastermind governing orderly execution of bodily processes throughout the day. In recent years, an emerging topic of broad interest is clock-modulatory agents, including small molecules from both synthetic and natural origins, and their potential applications in disease models. Nobiletin is a naturally occurring flavonoid with the greatest abundance found in citrus peels. Extensive research has shown that Nobiletin is endowed with a wide range of biological activities, yet its mechanism of action was unclear. We recently found that, through unbiased chemical screening, Nobiletin impinges on the clock machinery to activate temporal control of downstream processes within the cell and throughout the body. Using animal models of diseases and aging, we and others illustrate potent beneficial effects of Nobiletin on cellular energetics in both periphery and brain to promote healthy aging. Given its excellent safety profile, Nobiletin may represent a promising candidate molecule for nutraceutical and chronotherapeutic development against chronic and age-related neurodegenerative diseases.